Universität zu Köln

Bohn, Barbara ORCID: 0000-0001-8363-943X, Moenkemoeller, Kirsten, Hilgard, Doerte, Dost, Axel, Schwab, Karl Otfried, Lilienthal, Eggert, Hammer, Elke, Hake, Kathrin, Fritsch, Maria, Gohlke, Bettina, de Beaufort, Carine and Holl, Reinhard W. (2018). Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg. Pediatr. Diabetes, 19 (5). S. 937 - 945. HOBOKEN: WILEY. ISSN 1399-5448

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Abstract

Objective: To investigate differences in cardiovascular risk factors and metabolic control in girls with type 1 diabetes with or without use of oral contraceptives (OC) from the multicenter diabetes prospective follow-up (DPV) registry. Methods: Twenty-four thousand eleven adolescent girls (13 to < 18 years of age) from Germany, Austria or Luxembourg with type 1 diabetes from the DPV registry were included in this cross-sectional study. Multivariable regression models were applied to compare clinical characteristics (hemoglobin A1c [HbA1(C)], blood pressure, serum lipids, body mass index) and lifestyle factors (smoking, physical inactivity, alcohol consumption) between girls with or without OC use. Confounders: age, diabetes duration and migration background. Statistical analysis: SAS 9.4. Results: In girls with type 1 diabetes and OC use, clinical characteristics and lifestyle factors were less favorable compared to non-users. Differences were most pronounced for the prevalence of dyslipidemia (OC-users: 40.0% vs non-users: 29.4; P <.0001) and the number of smokers (OC-users: 25.9% vs non-users: 12.5%; P <.0001). OC use, sociodemographic characteristics and lifestyle factors explained between 1 and 7% of the population variance in serum lipids and blood pressure. The use of OC explained a small additional proportion in all variables considered (<1%). Conclusions: OC use in adolescent girls with type 1 diabetes was associated with a poorer cardiovascular risk profile. Biological risk factors were partly explained by a clustering of sociodemographic and lifestyle factors with a small additional contribution of OC use. Prescription of OC should therefore be combined with a screening for cardiovascular risk factors and targeted education.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bohn, Barbara UNSPECIFIED orcid.org/0000-0001-8363-943X UNSPECIFIED Moenkemoeller, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilgard, Doerte UNSPECIFIED UNSPECIFIED UNSPECIFIED Dost, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwab, Karl Otfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Lilienthal, Eggert UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammer, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Hake, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritsch, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Gohlke, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED de Beaufort, Carine UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179244
DOI:	10.1111/pedi.12656
Journal or Publication Title:	Pediatr. Diabetes
Volume:	19
Number:	5
Page Range:	S. 937 - 945
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-5448
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METABOLIC-CONTROL; WOMEN; CHILDREN; PREGNANCY; MELLITUS; SMOKING; MANAGEMENT; BEHAVIORS; EXPOSURES; TRACKING Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17924