Universität zu Köln

Walker, Zuzana ORCID: 0000-0001-7346-8200, Gandolfo, Federica, Orini, Stefania, Garibotto, Valentina ORCID: 0000-0003-2422-698X, Agosta, Federica ORCID: 0000-0003-3121-4979, Arbizu, Javier ORCID: 0000-0002-8370-5510, Bouwman, Femke, Drzezga, Alexander, Nestor, Peter ORCID: 0000-0002-5860-5921, Boccardi, Marina ORCID: 0000-0001-6744-8246, Altomare, Daniele ORCID: 0000-0003-1905-8993, Festari, Cristina ORCID: 0000-0003-3597-5097 and Nobili, Flavio ORCID: 0000-0001-9811-0897 (2018). Clinical utility of FDG PET in Parkinson's disease and atypical parkinsonism associated with dementia. Eur. J. Nucl. Med. Mol. Imaging, 45 (9). S. 1534 - 1546. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

There are no comprehensive guidelines for the use of FDG PET in the following three clinical scenarios: (1) diagnostic work-up of patients with idiopathic Parkinson's disease (PD) at risk of future cognitive decline, (2) discriminating idiopathic PD from progressive supranuclear palsy, and (3) identifying the underlying neuropathology in corticobasal syndrome. We therefore performed three literature searches and evaluated the selected studies for quality of design, risk of bias, inconsistency, imprecision, indirectness and effect size. Critical outcomes were the sensitivity, specificity, accuracy, positive/negative predictive value, area under the receiving operating characteristic curve, and positive/negative likelihood ratio of FDG PET in detecting the target condition. Using the Delphi method, a panel of seven experts voted for or against the use of FDG PET based on published evidence and expert opinion. Of 91 studies selected from the three literature searches, only four included an adequate quantitative assessment of the performance of FDG PET. The majority of studies lacked robust methodology due to lack of critical outcomes, inadequate gold standard and no head-to-head comparison with an appropriate reference standard. The panel recommended the use of FDG PET for all three clinical scenarios based on nonquantitative evidence of clinical utility. Despite widespread use of FDG PET in clinical practice and extensive research, there is still very limited good quality evidence for the use of FDG PET. However, in the opinion of the majority of the panellists, FDG PET is a clinically useful imaging biomarker for idiopathic PD and atypical parkinsonism associated with dementia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Walker, Zuzana UNSPECIFIED orcid.org/0000-0001-7346-8200 UNSPECIFIED Gandolfo, Federica UNSPECIFIED UNSPECIFIED UNSPECIFIED Orini, Stefania UNSPECIFIED UNSPECIFIED UNSPECIFIED Garibotto, Valentina UNSPECIFIED orcid.org/0000-0003-2422-698X UNSPECIFIED Agosta, Federica UNSPECIFIED orcid.org/0000-0003-3121-4979 UNSPECIFIED Arbizu, Javier UNSPECIFIED orcid.org/0000-0002-8370-5510 UNSPECIFIED Bouwman, Femke UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestor, Peter UNSPECIFIED orcid.org/0000-0002-5860-5921 UNSPECIFIED Boccardi, Marina UNSPECIFIED orcid.org/0000-0001-6744-8246 UNSPECIFIED Altomare, Daniele UNSPECIFIED orcid.org/0000-0003-1905-8993 UNSPECIFIED Festari, Cristina UNSPECIFIED orcid.org/0000-0003-3597-5097 UNSPECIFIED Nobili, Flavio UNSPECIFIED orcid.org/0000-0001-9811-0897 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180357
DOI:	10.1007/s00259-018-4031-2
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	45
Number:	9
Page Range:	S. 1534 - 1546
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGRESSIVE SUPRANUCLEAR PALSY; CEREBRAL GLUCOSE-METABOLISM; POSITRON-EMISSION-TOMOGRAPHY; DIFFERENTIAL-DIAGNOSIS; F-18-FDG PET; CORTICOBASAL SYNDROME; COGNITIVE IMPAIRMENT; BRAIN NETWORKS; PATTERNS; PSP Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18035