Universität zu Köln

Hedderich, Dennis M., Weiss, Kilian ORCID: 0000-0003-4295-4585, Spiro, Judith E., Giese, Daniel ORCID: 0000-0002-3925-4441, Beck, Gabriele M., Maintz, David and Persigehl, Thorsten (2018). Clinical Evaluation of Free-Breathing Contrast-Enhanced T1w MRI of the Liver using Pseudo Golden Angle Radial k-Space Sampling. Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr., 190 (7). S. 601 - 610. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-9010

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Abstract

Purpose Contrast-enhanced T1-weighted MR imaging of the liver is typically acquired using breath-hold techniques to reduce motion artifacts and to allow for optimal diagnostic image quality. Insufficient breath-holds during MR data collection can cause severe reduction of image quality up to the point of being non-diagnostic. The aim of this study was to evaluate the subjective and objective clinical image quality of a novel free-breathing radial k-space sampling MR technique. Materials and Methods Consent for this study was given by the local IRB committee. 86 patients who underwent both breath-hold (BH) and free-breathing (FB) late-phase contrast T1w-FS-FFE liver MRI using conventional BH Cartesian (Cartesian-eTHRIVE) and FB pseudo golden angle radial k-space sampling (Radial-eTHRIVE) were included in this retrospective analysis. Subjective analysis comprised 5-point Likert scale ratings (1 = very good; 5 = non-diagnostic) for artifact impact, anatomic sharpness, vessel sharpness, contrast impression, and overall diagnostic quality. Relative signal intensities in different ROIs were compared between Cartesian-eTHRIVE and Radial-eTHRIVE. For statistical differences paired Wilcoxon test and paired t-test have been performed (p < 0.05). Results The MR scan time was significantly longer for FB Radial-eTHRIVE (2min, 54 s) compared to BH Cartesian-eTHRIVE (0 min 15 s). Cartesian-eTHRIVE demonstrated a superior subjective contrast impression and objective measurements revealed an increased lesion-to-liver-contrast for hypointense liver lesions (Hypo-LTLC: 0.33 +/- 0.19 vs. 0.20 +/- 0.11; p = 0.000), while no difference was observed for hyperintense liver lesions (Hyper-LTLC). Subjective evaluation showed superior anatomic sharpness ratings by both readers for Radial-eTHRIVE. Most importantly, in a subgroup analysis of patients who were unable to perform adequate breath-holds, free-breathing Radial-eTHRIVE still demonstrated good subjective image quality. Conclusion Free-breathing, radial k-space sampling T1w MRI of the liver delivers high diagnostic image quality, especially in patients who are unable to adequately perform breath-hold maneuvers. Thus, Radial-eTHRIVE can be an important clinical alternative in patients with impaired respiration status.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hedderich, Dennis M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Kilian UNSPECIFIED orcid.org/0000-0003-4295-4585 UNSPECIFIED Spiro, Judith E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giese, Daniel UNSPECIFIED orcid.org/0000-0002-3925-4441 UNSPECIFIED Beck, Gabriele M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180703
DOI:	10.1055/s-0044-101263
Journal or Publication Title:	Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr.
Volume:	190
Number:	7
Page Range:	S. 601 - 610
Date:	2018
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-9010
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GRADIENT-ECHO SEQUENCE; MAGNETIC-RESONANCE; GADOXETIC ACID; GADOBENATE DIMEGLUMINE; IMAGE QUALITY; DISODIUM; CT; ACQUISITION; CARCINOMA; DIAGNOSIS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18070