Universität zu Köln

Wahba, R., Stippel, D. and Bruns, C. (2018). Role of visceral surgery in oligometastases of non-gastrointestinal tumors. Chirurg, 89 (7). S. 523 - 529. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0385

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Abstract

Patients with oligometastatic disease can benefit from local treatment of the metastases. Under these premises the resection of liver metastases and visceral metastases of non-gastrointestinal tumors is performed increasingly more frequently in selected patients. The aim of this study was to evaluate the role of visceral oncological surgery in hepatic oligometastatic disease of non-gastrointestinal tumors according to the currently available literature. A systematic search of MEDLINE and PubMed was carried out focusing on the topics of oligometastases, liver resection and metastectomy for breast cancer, renal cell carcinoma, malignant melanoma, ovarian cancer and non-small cell lung cancer. The evidence is limited to retrospective studies and case series. In selected patients after liver resection and multimodal therapy 5aEuroyear survival rates of 53% (breast cancer), 62% (renal cell carcinoma), 22% (malignant melanoma) and 50% (ovarian cancer) are described. For lung cancer (NSCLC) median survival was 12 month. Prognostic factors n were a disease free survival of > 12 months, R0-resection, response to systemic therapy and extra hepatic/extra abdominal metastases. These could be selection criteria for liver resection. Recurrence liver resection, resection of the pancreas and cytoreductive surgery including multivisceral resection (ovarian cancer) could also improve survival. Regarding limited evidence patients with oligometastatic disease origin from non-gastrointestinal tumors could benefit from liver resection. Tumor biology and response to targeted individualized systemic therapy become more important in this scenario.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wahba, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stippel, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-181782
DOI:	10.1007/s00104-018-0647-9
Journal or Publication Title:	Chirurg
Volume:	89
Number:	7
Page Range:	S. 523 - 529
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0385
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METASTATIC BREAST-CANCER; RENAL-CELL CARCINOMA; EPITHELIAL OVARIAN-CANCER; LONG-TERM SURVIVORS; LIVER RESECTION; HEPATIC RESECTION; DIAGNOSIS; MULTICENTER; GUIDELINES; RECURRENT Multiple languages Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18178