Shimabukuro-Vornhagen, Alexander ORCID: 0000-0002-2351-7294, Goedel, Philipp, Subklewe, Marion, Stemmler, Hans Joachim, Schloesser, Hans Anton, Schlaak, Max, Kochanek, Matthias, Boell, Boris and von Bergwelt-Baildon, Michael S. (2018). Cytokine release syndrome. J. Immunother. Cancer, 6. LONDON: BMC. ISSN 2051-1426

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Abstract

During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific T-cell engaging (BiTE) single-chain antibody constructs and chimeric antigen receptor (CAR) T cells have shown remarkable efficacy in clinical trials and some of these agents have already received regulatory approval. However, along with growing experience in the clinical application of these potent immunotherapeutic agents comes the increasing awareness of their inherent and potentially fatal adverse effects, most notably the cytokine release syndrome (CRS). This review provides a comprehensive overview of the mechanisms underlying CRS pathophysiology, risk factors, clinical presentation, differential diagnoses, and prognostic factors. In addition, based on the current evidence we give practical guidance to the management of the cytokine release syndrome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Shimabukuro-Vornhagen, AlexanderUNSPECIFIEDorcid.org/0000-0002-2351-7294UNSPECIFIED
Goedel, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Subklewe, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stemmler, Hans JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schloesser, Hans AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaak, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kochanek, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boell, BorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Bergwelt-Baildon, Michael S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-182824
DOI: 10.1186/s40425-018-0343-9
Journal or Publication Title: J. Immunother. Cancer
Volume: 6
Date: 2018
Publisher: BMC
Place of Publication: LONDON
ISSN: 2051-1426
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RECEPTOR T-CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; INTERNATIONAL CONSENSUS; MACROPHAGE ACTIVATION; ADVERSE EVENT; THERAPY; BLINATUMOMAB; CD19; IL-6; MANAGEMENTMultiple languages
Oncology; ImmunologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18282

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