Universität zu Köln

Splinter, Anouck, Tjaden, Lidwien A., Haverman, Lotte, Adams, Brigitte, Collard, Laure, Cransberg, Karlien, van Dyck, Maria, Van Hoeck, Koen J., Hoppe, Bernd, Koster-Kamphuis, Linda ORCID: 0000-0002-9971-995X, Lilien, Marc R., Raes, Ann, Taylan, Christina, Grootenhuis, Martha A. and Groothoff, Jaap W. (2018). Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life. Qual. Life Res., 27 (6). S. 1445 - 1455. DORDRECHT: SPRINGER. ISSN 1573-2649

Full text not available from this repository.

Abstract

To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors. All prevalent end-stage renal disease (ESRD) patients aged 8-18 years who spent at least 6 months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4.0 (PedsQL (TM)) questionnaire. We determined the differences between groups on PedsQL (TM) mean scores, the proportion of children with an impaired HRQoL (ae<yen> 1 SD lower than the healthy norm), the proportion of problems on individual items of the PedsQL (TM), and the effect of time on current treatment. Linear regression models were used to explore determinants of HRQoL. 192 out of 278 patients (20% preemptive transplant, 58% non-preemptive transplant, 22% dialysis) filled in the PedsQL (TM) (response rate 69%). Independent of treatment modality, patients had significantly lower mean scores and consequently higher proportions of impaired HRQoL on almost all domains compared to the healthy norm and other chronic health conditions. Patients with a preemptive transplant only reported higher scores on physical health compared to the other treatment modalities. Having comorbidities was the most important determinant associated with lower HRQoL scores. Dialysis and renal transplantation both have a severe impact on the HRQoL of children with ESRD. Physicians should be aware of this continuous burden. Furthermore, to develop tailored interventions for children with ESRD, qualitative studies are needed to gain more insight in the determinants of HRQoL in the different treatment modalities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Splinter, Anouck UNSPECIFIED UNSPECIFIED UNSPECIFIED Tjaden, Lidwien A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haverman, Lotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Adams, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Collard, Laure UNSPECIFIED UNSPECIFIED UNSPECIFIED Cransberg, Karlien UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dyck, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Hoeck, Koen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Koster-Kamphuis, Linda UNSPECIFIED orcid.org/0000-0002-9971-995X UNSPECIFIED Lilien, Marc R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Raes, Ann UNSPECIFIED UNSPECIFIED UNSPECIFIED Taylan, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Grootenhuis, Martha A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Groothoff, Jaap W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185697
DOI:	10.1007/s11136-018-1789-4
Journal or Publication Title:	Qual. Life Res.
Volume:	27
Number:	6
Page Range:	S. 1445 - 1455
Date:	2018
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-2649
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language KIDNEY-TRANSPLANTATION; PEDIATRIC-PATIENTS; DISEASE; CHILDHOOD; ESRD; PERSPECTIVES; NETHERLANDS; PATIENT; CARE Multiple languages Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18569