Krause-Kyora, Ben ORCID: 0000-0001-9435-2872, Nutsua, Marcel, Boehme, Lisa, Pierini, Federica, Pedersen, Dorthe Dangvard ORCID: 0000-0002-4709-9170, Kornell, Sabin-Christin, Drichel, Dmitriy ORCID: 0000-0001-5978-3458, Bonazzi, Marion, Moebus, Lena, Tarp, Peter, Susat, Julian, Bosse, Esther, Willburger, Beatrix, Schmidt, Alexander H., Sauter, Juergen, Franke, Andre, Wittig, Michael, Caliebe, Amke, Nothnagel, Michael ORCID: 0000-0001-8305-7114, Schreiber, Stefan, Boldsen, Jesper L., Lenz, Tobias L. and Nebel, Almut (2018). Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans. Nat. Commun., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Leprosy, a chronic infectious disease caused by Mycobacterium leprae (M. leprae), was very common in Europe till the 16th century. Here, we perform an ancient DNA study on medieval skeletons from Denmark that show lesions specific for lepromatous leprosy (LL). First, we test the remains for M. leprae DNA to confirm the infection status of the individuals and to assess the bacterial diversity. We assemble 10 complete M. leprae genomes that all differ from each other. Second, we evaluate whether the human leukocyte antigen allele DRB1*15:01, a strong LL susceptibility factor in modern populations, also predisposed medieval Europeans to the disease. The comparison of genotype data from 69 M. leprae DNA-positive LL cases with those from contemporary and medieval controls reveals a statistically significant association in both instances. In addition, we observe that DRB1*15:01 co-occurs with DQB1*06:02 on a haplotype that is a strong risk factor for inflammatory diseases today.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Krause-Kyora, BenUNSPECIFIEDorcid.org/0000-0001-9435-2872UNSPECIFIED
Nutsua, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehme, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pierini, FedericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pedersen, Dorthe DangvardUNSPECIFIEDorcid.org/0000-0002-4709-9170UNSPECIFIED
Kornell, Sabin-ChristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drichel, DmitriyUNSPECIFIEDorcid.org/0000-0001-5978-3458UNSPECIFIED
Bonazzi, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moebus, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tarp, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Susat, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bosse, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willburger, BeatrixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Alexander H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauter, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittig, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caliebe, AmkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nothnagel, MichaelUNSPECIFIEDorcid.org/0000-0001-8305-7114UNSPECIFIED
Schreiber, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boldsen, Jesper L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenz, Tobias L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nebel, AlmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-187104
DOI: 10.1038/s41467-018-03857-x
Journal or Publication Title: Nat. Commun.
Volume: 9
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MULTIPLE-SCLEROSIS; HIGH-RESOLUTION; MYCOBACTERIUM-LEPRAE; LEPROMATOUS LEPROSY; HIGH-THROUGHPUT; ASSOCIATION; ALIGNMENT; SEQUENCE; VARIANT; GENOMEWIDEMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18710

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