Universität zu Köln

Geissler, Julia ORCID: 0000-0003-1878-9647, Jans, Thomas, Banaschewski, Tobias, Becker, Katja ORCID: 0000-0003-4858-5127, Renner, Tobias, Brandeis, Daniel, Doepfner, Manfred, Dose, Christina, Hautmann, Christopher, Holtmann, Martin, Jenkner, Carolin, Millenet, Sabina and Romanos, Marcel ORCID: 0000-0001-7628-8299 (2018). Individualised short-term therapy for adolescents impaired by attention-deficit/hyperactivity disorder despite previous routine care treatment (ESCAadol)-Study protocol of a randomised controlled trial within the consortium ESCAlife. Trials, 19. LONDON: BMC. ISSN 1745-6215

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Abstract

Background: Despite the high persistence rate of attention-deficit/hyperactivity disorder (ADHD) throughout the lifespan, there is a considerable gap in knowledge regarding effective treatment strategies for adolescents with ADHD. This group in particular often shows substantial psychosocial impairment, low compliance and insufficient response to psychopharmacological interventions. Effective and feasible treatments should further consider the developmental shift in ADHD symptoms, comorbidity and psychosocial adversity as well as family dysfunction. Thus, individualised interventions for adolescent ADHD should comprise a multimodal treatment strategy. The randomised controlled ESCAadol study addresses the needs of this patient group and compares the outcome of short-term cognitive behavioural therapy with parent-based telephone-assisted self-help. Methods/design: In step 1, 160 adolescents aged 12 to 17 years with a diagnosis of ADHD will undergo a treatment as usual (TAU) observation phase of 1 month. In step 2, those still severely affected are randomised to the intervention group with an Individualised Modular Treatment Programme (IMTP) or a telephone-assisted self-help programme for parents (TASH) as an active control condition. The IMTP was specifically designed for the needs of adolescent ADHD. It comprises 10 sessions of individual cognitive behavioural therapy with the adolescents and/or the parents, for which participants choose three out of 10 available focus modules (e.g. organisational skills and planning, emotion regulation, problem solving and stress management, dysfunctional family communication). TASH combines a bibliotherapeutic component with 10 counselling sessions for the parents via telephone. Primary outcome is the change in ADHD symptoms in a clinician-rated diagnostic interview. Outcomes are assessed at inclusion into the study, after the TAU phase, after the intervention phase and after a further 12-week follow-up period. The primary statistical analysis will be by intention-to-treat, using linear regression models. Additionally, we will analyse psychometric and biological predictors and moderators of treatment response. Discussion: ESCAadol compares two short-term non-pharmacological interventions as cost-efficient and feasible treatment options for adolescent ADHD, addressing the specific needs and obstacles to treatment success in this group. We aim to contribute to personalised medicine for adolescent ADHD intended to be implemented in routine clinical care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Geissler, Julia UNSPECIFIED orcid.org/0000-0003-1878-9647 UNSPECIFIED Jans, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Banaschewski, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Katja UNSPECIFIED orcid.org/0000-0003-4858-5127 UNSPECIFIED Renner, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandeis, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Doepfner, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Dose, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hautmann, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmann, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jenkner, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Millenet, Sabina UNSPECIFIED UNSPECIFIED UNSPECIFIED Romanos, Marcel UNSPECIFIED orcid.org/0000-0001-7628-8299 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-188998
DOI:	10.1186/s13063-018-2635-2
Journal or Publication Title:	Trials
Volume:	19
Date:	2018
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1745-6215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEFICIT HYPERACTIVITY DISORDER; EXTERNALIZING PROBLEM BEHAVIOR; AFFECTIVE REACTIVITY INDEX; AGE-DEPENDENT DECLINE; YOUTH SELF-REPORT; SUBSTANTIA-NIGRA; FOLLOW-UP; PARENTING INTERVENTIONS; PSYCHOMETRIC PROPERTIES; MULTIMODAL TREATMENT Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18899