Universität zu Köln

Urban, Maximilian J., Both, Steffen, Zhou, Chao ORCID: 0000-0003-1185-9964, Kuzyk, Anton ORCID: 0000-0001-8060-6122, Lindfors, Klas ORCID: 0000-0002-6482-5605, Weiss, Thomas and Liu, Na (2018). Gold nanocrystal-mediated sliding of doublet DNA origami filaments. Nat. Commun., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Sliding is one of the fundamental mechanical movements in machinery. In macroscopic systems, double-rack pinion machines employ gears to slide two linear tracks along opposite directions. In microscopic systems, kinesin-5 proteins crosslink and slide apart antiparallel microtubules, promoting spindle bipolarity and elongation during mitosis. Here we demonstrate an artificial nanoscopic analog, in which gold nanocrystals can mediate coordinated sliding of two antiparallel DNA origami filaments powered by DNA fuels. Stepwise and reversible sliding along opposite directions is in situ monitored and confirmed using fluorescence spectroscopy. A theoretical model including different energy transfer mechanisms is developed to understand the observed fluorescence dynamics. We further show that such sliding can also take place in the presence of multiple DNA sidelocks that are introduced to inhibit the relative movements. Our work enriches the toolbox of DNA-based nanomachinery, taking one step further toward the vision of molecular nanofactories.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Urban, Maximilian J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Both, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Chao UNSPECIFIED orcid.org/0000-0003-1185-9964 UNSPECIFIED Kuzyk, Anton UNSPECIFIED orcid.org/0000-0001-8060-6122 UNSPECIFIED Lindfors, Klas UNSPECIFIED orcid.org/0000-0002-6482-5605 UNSPECIFIED Weiss, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Na UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189354
DOI:	10.1038/s41467-018-03882-w
Journal or Publication Title:	Nat. Commun.
Volume:	9
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Physical Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELF-ORGANIZATION; MOLECULAR MOTOR; WALKER; MICROTUBULES; PROTEINS; KINETICS; DEVICES; WALKING; MOTION; MOVES Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18935