Universität zu Köln

Suwelack, Barbara, Woermann, Viktoriya, Berger, Klaus, Gerss, Joachim, Wolters, Heiner, Vitinius, Frank and Burgmer, Markus (2018). Investigation of the physical and psychosocial outcomes after living kidney donation - a multicenter cohort study (SoLKiD - Safety of Living Kidney Donors). BMC Nephrol., 19. LONDON: BIOMED CENTRAL LTD. ISSN 1471-2369

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Abstract

Background: Over the last years, living kidney donation (LKD) has been established for patients with endstage renal failure as an alternative to post mortem donation, which is limited by organ scarcity and long lasting waiting periods. From an ethical perspective, the increase in LKD requires that donors' physical, psychological, and social harm has to be minimized as much as possible and the risk should not exceed the generally expected consequences of nephrectomy. Despite of numerous, mainly retrospective studies about the postoperative outcome of LKD over the last years from different countries, it becomes apparent that there is a lack of comprehensive prospective multicenter research in this field worldwide. Therefore, the main aim of the study is to examine the physical and psychosocial outcome of living kidney donors in a prospective design before and after transplantation in an interdisciplinary approach (surgery, nephrology, psychosocial medicine). Methods/design: The goal of the study is to investigate such aspects as the impact of gender-and age-specific factors on LKD outcome, donor outcome in correlation to the health status of the recipient, the medical and psychosocial risk of a healthy subject undergoing the LKD procedure. The study is carried out as a nationwide multicenter study. All adult living kidney donors with sufficient knowledge in the German, Russian, or Turkish language, informed consent, and place of residence in Germany are included. In a naturalistic design (cohort study), clinical data and self-report measures (questionnaires) of 320 donors are collected before and 8 weeks, 6 and 12 months after donation. Primary outcome parameters are the kidney function (estimated GFR) and the quality of life (SF-36) of the donor. Secondary outcome parameters are data about physical (e.g., wound healing, blood pressure) and psychosocial (fatigue, depression, anxiety, somatization) outcome after donation. Discussion: Previous studies on the postoperative outcome of living kidney donors have methodological limitations and/or were carried out in countries with different healthcare systems, e.g. United States, Norway, Canada, United Kingdom. Thus, results cannot be generalized and are not particularly applicable to the risks of mainly caucasian living kidney donors in the German healthcare system. The study design overcomes these disadvantages in that it provides a prospective multicenter design.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Suwelack, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Woermann, Viktoriya UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerss, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolters, Heiner UNSPECIFIED UNSPECIFIED UNSPECIFIED Vitinius, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgmer, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189535
DOI:	10.1186/s12882-018-0871-z
Journal or Publication Title:	BMC Nephrol.
Volume:	19
Date:	2018
Publisher:	BIOMED CENTRAL LTD
Place of Publication:	LONDON
ISSN:	1471-2369
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; COGNITIVE EMOTION REGULATION; LONG-TERM CONSEQUENCES; STAGE RENAL-DISEASE; BLOOD-PRESSURE; HEALTH SURVEY; SHORT FORM-36; FOLLOW-UP; TRANSPLANTATION; NEPHRECTOMY Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18953