Universität zu Köln

Hartmann, Michael ORCID: 0000-0003-4828-958X, Zeier, Tatyana, Bernsdorff, Friederike ORCID: 0000-0003-3457-2034, Reichel-Deland, Vanessa, Kim, Denis, Hohmann, Michele, Scholten, Nicola, Schuck, Stefan ORCID: 0000-0002-3959-4884, Braeutigam, Andrea, Hoelzel, Torsten, Ganter, Christian and Zeier, Juergen (2018). Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell, 173 (2). S. 456 - 486. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

Full text not available from this repository.

Abstract

Following a previous microbial inoculation, plants can induce broad-spectrum immunity to pathogen infection, a phenomenon known as systemic acquired resistance (SAR). SAR establishment in Arabidopsis thaliana is regulated by the Lys catabolite pipecolic acid (Pip) and flavin-dependent-monooxygenase1 (FMO1). Here, we show that elevated Pip is sufficient to induce an FMO1-dependent transcriptional reprogramming of leaves that is reminiscent of SAR. In planta and in vitro analyses demonstrate that FMO1 functions as a pipecolate N-hydroxylase, catalyzing the biochemical conversion of Pip to N-hydroxypipecolic acid (NHP). NHP-systemically accumulates in plants after microbial attack. When exogenously applied, it overrides the defect of NHP-deficient fmo1 in acquired resistance and acts as a potent inducer of plant immunity to bacterial and oomycete infection. Our work has identified a pathogen-inducible L-Lys catabolic pathway in plants that generates the N-hydroxylated amino acid NHP as a critical regulator of systemic acquired resistance to pathogen infection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hartmann, Michael UNSPECIFIED orcid.org/0000-0003-4828-958X UNSPECIFIED Zeier, Tatyana UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernsdorff, Friederike UNSPECIFIED orcid.org/0000-0003-3457-2034 UNSPECIFIED Reichel-Deland, Vanessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Denis UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohmann, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholten, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuck, Stefan UNSPECIFIED orcid.org/0000-0002-3959-4884 UNSPECIFIED Braeutigam, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelzel, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Ganter, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeier, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-189635
DOI:	10.1016/j.cell.2018.02.049
Journal or Publication Title:	Cell
Volume:	173
Number:	2
Page Range:	S. 456 - 486
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4172
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACQUIRED-RESISTANCE; SALICYLIC-ACID; DEPENDENT MONOOXYGENASE; BIOSYNTHESIS PATHWAY; ARABIDOPSIS-THALIANA; DEFENSE RESPONSES; PIPECOLIC ACID; CELL-DEATH; ACTIVATION; CATALYZES Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18963