Sadda, Srinivas R., Guymer, Robyn ORCID: 0000-0002-9441-4356, Holz, Frank G., Schmitz-Valckenberg, Steffen, Curcio, Christine A., Bird, Alan C., Blodi, Barbara A., Bottoni, Ferdinando, Chakravarthy, Usha ORCID: 0000-0002-2606-3734, Chew, Emily Y., Csaky, Karl, Danis, Ronald P., Fleckenstein, Monika ORCID: 0000-0001-8321-8037, Freund, K. Bailey ORCID: 0000-0002-7888-9773, Grunwald, Juan ORCID: 0000-0002-5973-6616, Hoyng, Carel B., Jaffe, Glenn J., Liakopoulos, Sandra, Mones, Jordi M., Pauleikhoff, Daniel, Rosenfeld, Philip J., Sarraf, David, Spaide, Richard F., Tadayoni, Ramin ORCID: 0000-0001-5616-3579, Tufail, Adnan, Wolf, Sebastian ORCID: 0000-0002-7467-7028 and Staurenghi, Giovanni ORCID: 0000-0002-2299-5251 (2018). Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT Classification of Atrophy Report 3. Ophthalmology, 125 (4). S. 537 - 549. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1549-4713

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Abstract

Purpose: To develop consensus terminology and criteria for defining atrophy based on OCT findings in the setting of age-related macular degeneration (AMD). Design: Consensus meeting. Participants: Panel of retina specialists, image reading center experts, retinal histologists, and optics engineers. Methods: As part of the Classification of Atrophy Meetings (CAM) program, an international group of experts surveyed the existing literature, performed a masked analysis of longitudinal multimodal imaging for a series of eyes with AMD, and reviewed the results of this analysis to define areas of agreement and disagreement. Through consensus discussions at 3 meetings over 12 months, a classification system based on OCT was proposed for atrophy secondary to AMD. Specific criteria were defined to establish the presence of atrophy. Main Outcome Measures: A consensus classification system for atrophy and OCT-based criteria to identify atrophy. Results: OCT was proposed as the reference standard or base imaging method to diagnose and stage atrophy. Other methods, including fundus autofluorescence, near-infrared reflectance, and color imaging, provided complementary and confirmatory information. Recognizing that photoreceptor atrophy can occur without retinal pigment epithelium (RPE) atrophy and that atrophy can undergo an evolution of different stages, 4 terms and histologic candidates were proposed: complete RPE and outer retinal atrophy (cRORA), incomplete RPE and outer retinal atrophy, complete outer retinal atrophy, and incomplete outer retinal atrophy. Specific OCT criteria to diagnose cRORA were proposed: (1) a region of hypertransmission of at least 250 mu m in diameter, (2) a zone of attenuation or disruption of the RPE of at least 250 mu m in diameter, (3) evidence of overlying photoreceptor degeneration, and (4) absence of scrolled RPE or other signs of an RPE tear. Conclusions: A classification system and criteria for OCT-defined atrophy in the setting of AMD has been proposed based on an international consensus. This classification is a more complete representation of changes that occur in AMD than can be detected using color fundus photography alone. Longitudinal information is required to validate the implied risk of vision loss associated with these terms. This system will enable such future studies to be undertaken using consistent definitions. (C) 2017 by the American Academy of Ophthalmology

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sadda, Srinivas R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guymer, RobynUNSPECIFIEDorcid.org/0000-0002-9441-4356UNSPECIFIED
Holz, Frank G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitz-Valckenberg, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curcio, Christine A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bird, Alan C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blodi, Barbara A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bottoni, FerdinandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chakravarthy, UshaUNSPECIFIEDorcid.org/0000-0002-2606-3734UNSPECIFIED
Chew, Emily Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Csaky, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danis, Ronald P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleckenstein, MonikaUNSPECIFIEDorcid.org/0000-0001-8321-8037UNSPECIFIED
Freund, K. BaileyUNSPECIFIEDorcid.org/0000-0002-7888-9773UNSPECIFIED
Grunwald, JuanUNSPECIFIEDorcid.org/0000-0002-5973-6616UNSPECIFIED
Hoyng, Carel B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaffe, Glenn J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liakopoulos, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mones, Jordi M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauleikhoff, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenfeld, Philip J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarraf, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spaide, Richard F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tadayoni, RaminUNSPECIFIEDorcid.org/0000-0001-5616-3579UNSPECIFIED
Tufail, AdnanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, SebastianUNSPECIFIEDorcid.org/0000-0002-7467-7028UNSPECIFIED
Staurenghi, GiovanniUNSPECIFIEDorcid.org/0000-0002-2299-5251UNSPECIFIED
URN: urn:nbn:de:hbz:38-190177
DOI: 10.1016/j.ophtha.2017.09.028
Journal or Publication Title: Ophthalmology
Volume: 125
Number: 4
Page Range: S. 537 - 549
Date: 2018
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1549-4713
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OPTICAL COHERENCE TOMOGRAPHY; SUBRETINAL DRUSENOID DEPOSITS; GEOGRAPHIC ATROPHY; FUNDUS AUTOFLUORESCENCE; PREDICTIVE-VALUE; GRADING SYSTEM; END-POINTS; MACULOPATHY; PROGRESSION; GROWTHMultiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19017

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