Universität zu Köln

Graef, Martin (2018). Lipid droplet-mediated lipid and protein homeostasis in budding yeast. FEBS Lett., 592 (8). S. 1291 - 1304. HOBOKEN: WILEY. ISSN 1873-3468

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Abstract

Lipid droplets are conserved specialized organelles that store neutral lipids. Our view on this unique organelle has evolved from a simple fat deposit to a highly dynamic and functionally diverse hub-one that mediates the buffering of fatty acid stress and the adaptive reshaping of lipid metabolism to promote membrane and organelle homeostasis and the integrity of central proteostasis pathways, including autophagy, which ensure stress resistance and cell survival. This Review will summarize the recent developments in the budding yeast Saccharomyces cerevisiae, as this model organism has been instrumental in deciphering the fundamental mechanisms and principles of lipid droplet biology and interconnecting lipid droplets with many unanticipated cellular functions applicable to many other cell systems.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Graef, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-190644
DOI:	10.1002/1873-3468.12996
Journal or Publication Title:	FEBS Lett.
Volume:	592
Number:	8
Page Range:	S. 1291 - 1304
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1873-3468
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FATTY-ACID DESATURASE; TRIACYLGLYCEROL LIPASE TGL3P; CDP-DIACYLGLYCEROL SYNTHASE; CEREVISIAE HYDROLASE LDH1P; NUCLEAR-MEMBRANE GROWTH; STERYL ESTER SYNTHESIS; SACCHAROMYCES-CEREVISIAE; PHOSPHATIDATE PHOSPHATASE; AUTOPHAGOSOME BIOGENESIS; ENDOPLASMIC-RETICULUM Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19064