Universität zu Köln

Deger, Moritz ORCID: 0000-0002-2775-2611, Seeholzer, Alexander and Gerstner, Wulfram (2018). Multicontact Co-operativity in Spike-Timing-Dependent Structural Plasticity Stabilizes Networks. Cereb. Cortex, 28 (4). S. 1396 - 1416. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of spine volume, a correlate of synaptic strength, can be tracked in vivo for weeks. Here, we present a combined model of structural and spike-timing-dependent plasticity that explains the multicontact configuration of synapses in adult neocortical networks under steady-state and lesion-induced conditions. Our plasticity rule with Hebbian and anti-Hebbian terms stabilizes both the postsynaptic firing rate and correlations between the pre- and postsynaptic activity at an active synaptic contact. Contacts appear spontaneously at a low rate and disappear if their strength approaches zero. Many presynaptic neurons compete to make strong synaptic connections onto a postsynaptic neuron, whereas the synaptic contacts of a given presynaptic neuron co-operate via postsynaptic firing. We find that cooperation of multiple synaptic contacts is crucial for stable, long-term synaptic memories. In simulations of a simplified network model of barrel cortex, our plasticity rule reproduces whisker-trimming-induced rewiring of thalamocortical and recurrent synaptic connectivity on realistic time scales.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Deger, Moritz UNSPECIFIED orcid.org/0000-0002-2775-2611 UNSPECIFIED Seeholzer, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerstner, Wulfram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-191623
DOI:	10.1093/cercor/bhx339
Journal or Publication Title:	Cereb. Cortex
Volume:	28
Number:	4
Page Range:	S. 1396 - 1416
Date:	2018
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM POTENTIATION; NEOCORTEX IN-VIVO; DENDRITIC SPINES; SYNAPTIC PLASTICITY; VISUAL-CORTEX; HOMEOSTATIC PLASTICITY; PYRAMIDAL NEURONS; ADULT CORTEX; CONNECTIVITY; MODEL Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19162