Mondal, Tanmoy, Juvvuna, Prasanna Kumar, Kirkeby, Agnete ORCID: 0000-0001-8203-6901, Mitra, Sanhita, Kosalai, Subazini Thankaswamy, Traxler, Larissa ORCID: 0000-0003-0974-3575, Hertwig, Falk ORCID: 0000-0003-4784-6516, Wernig-Zorc, Sara, Miranda, Caroline, Deland, Lily, Volland, Ruth, Bartenhagen, Christoph, Bartsch, Deniz, Bandaru, Sashidhar, Engesser, Anne, Subhash, Santhilal ORCID: 0000-0002-0077-4597, Martinsson, Tommy ORCID: 0000-0002-9403-3123, Caren, Helena ORCID: 0000-0002-8584-555X, Akyurek, Levent M., Kurian, Leo ORCID: 0000-0001-7466-5169, Kanduri, Meena, Huarte, Maite ORCID: 0000-0003-3753-6493, Kogner, Per ORCID: 0000-0002-2202-9694, Fischer, Matthias and Kanduri, Chandrasekhar (2018). Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis. Cancer Cell, 33 (3). S. 417 - 442. CAMBRIDGE: CELL PRESS. ISSN 1878-3686

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Abstract

Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functional synergy between 6p22lncRNAs results in an undifferentiated state that is maintained by a gene-regulatory network, including SOX9 located on 17q, a region frequently gained in NB. 6p22lncRNAs regulate SOX9 expression by controlling CHD7 stability via modulating the cellular localization of USP36, encoded by another 17q gene. This regulatory nexus between 6p22.3 and 17q regions may lead to potential NB treatment strategies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mondal, TanmoyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juvvuna, Prasanna KumarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirkeby, AgneteUNSPECIFIEDorcid.org/0000-0001-8203-6901UNSPECIFIED
Mitra, SanhitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosalai, Subazini ThankaswamyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Traxler, LarissaUNSPECIFIEDorcid.org/0000-0003-0974-3575UNSPECIFIED
Hertwig, FalkUNSPECIFIEDorcid.org/0000-0003-4784-6516UNSPECIFIED
Wernig-Zorc, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miranda, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deland, LilyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volland, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartenhagen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartsch, DenizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bandaru, SashidharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engesser, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Subhash, SanthilalUNSPECIFIEDorcid.org/0000-0002-0077-4597UNSPECIFIED
Martinsson, TommyUNSPECIFIEDorcid.org/0000-0002-9403-3123UNSPECIFIED
Caren, HelenaUNSPECIFIEDorcid.org/0000-0002-8584-555XUNSPECIFIED
Akyurek, Levent M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurian, LeoUNSPECIFIEDorcid.org/0000-0001-7466-5169UNSPECIFIED
Kanduri, MeenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huarte, MaiteUNSPECIFIEDorcid.org/0000-0003-3753-6493UNSPECIFIED
Kogner, PerUNSPECIFIEDorcid.org/0000-0002-2202-9694UNSPECIFIED
Fischer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanduri, ChandrasekharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-192821
DOI: 10.1016/j.ccell.2018.01.020
Journal or Publication Title: Cancer Cell
Volume: 33
Number: 3
Page Range: S. 417 - 442
Date: 2018
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1878-3686
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LONG NONCODING RNAS; HIGH-RISK NEUROBLASTOMA; NEURAL CREST; PROSTATE-CANCER; STEM-CELLS; DIFFERENTIATION; GENES; ACTIVATION; LANDSCAPE; INSIGHTSMultiple languages
Oncology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19282

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