Mohty, Mohamad, Azar, Nabih, Chabannon, Christian ORCID: 0000-0002-3755-4889, Le Gouill, Steven, Karlin, Lionel, Farina, Lucia, Milkovich, Gary, Ostermann, Helmut, Glass, Bertram, Noppeney, Richard, Kron, Florian, Kron, Anna and Huebel, Kai (2018). Plerixafor in poor mobilizers with non-Hodgkin's lymphoma: a multi-center time-motion analysis. Bone Marrow Transplant., 53 (3). S. 246 - 255. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

High-dose chemotherapy alongside peripheral blood stem cell (PBSC) infusion has become the standard of care in different hematologic malignancies. The goal of PBSC mobilization is to allow collection of sufficient CD34+ cells to proceed to transplantation. The current mobilization regimen with granulocyte colony-stimulating factor (G-CSF), alone or in combination with chemotherapy, still fails in 10-25% of patients. Plerixafor is able to rescue most of these patients from mobilization failure. In this study, we investigated the impact of plerixafor on the cost and time spent on apheresis in patients who were considered poor mobilizers, with < 20x10(6)/mu l peripheral CD34+ cells after mobilization but prior to apheresis. Patient hospital records from ten centers in three European countries were reviewed and compared during two time periods, namely prior and after plerixafor introduction to the market. During the plerixafor period, patients spent less time on apheresis (350 vs. 461 min). Poor mobilizers given plerixafor collected more CD34+ cells during the first apheresis session, leading to a decrease in the average number of apheresis sessions needed. The total apheresis yield was unaffected. This analysis shows that the use of plerixafor lessens the time-effort associated with the management of poor mobilizers and reduces apheresis costs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mohty, MohamadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azar, NabihUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chabannon, ChristianUNSPECIFIEDorcid.org/0000-0002-3755-4889UNSPECIFIED
Le Gouill, StevenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karlin, LionelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farina, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milkovich, GaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostermann, HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glass, BertramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noppeney, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kron, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kron, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebel, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-193171
DOI: 10.1038/s41409-017-0033-0
Journal or Publication Title: Bone Marrow Transplant.
Volume: 53
Number: 3
Page Range: S. 246 - 255
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEM-CELL MOBILIZATION; HIGH-DOSE CHEMOTHERAPY; MULTIPLE-MYELOMA; COST-EFFECTIVENESS; RESOURCE UTILIZATION; BLOOD; TRANSPLANTATION; SUPPORT; IMPACT; COUNTMultiple languages
Biophysics; Oncology; Hematology; Immunology; TransplantationMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19317

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