Kapinova, Andrea, Kubatka, Peter, Zubor, Pavol, Golubnitschaja, Olga, Dankova, Zuzana ORCID: 0000-0001-7215-148X, Uramova, Sona, Pilchova, Ivana, Caprnda, Martin, Opatrilova, Radka, Richnavsky, Jan, Kruzliak, Peter and Danko, Jan (2018). The hypoxia-responsive long non-coding RNAs may impact on the tumor biology and subsequent management of breast cancer. Biomed. Pharmacother., 99. S. 51 - 59. ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 1950-6007

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Abstract

Long non-coding RNAs (lncRNAs) are DNA transcripts longer than 200 nucleotides without protein-coding potential. As they are key regulators of gene expression at chromatic, transcriptional and posttranscriptional level, they play important role in various biological and pathological processes. Dysregulation of lncRNAs has been observed in several diseases including cancer. Breast cancer is heterogeneous disease with many molecular subtypes specific in different prognosis and treatment responses. Hypoxia, a common micro-environmental feature of rapidly growing tumour is associated with metastases, recurrences and resistance to therapy. Aberrant expression of hypoxia related lncRNAs significantly correlates with poor outcomes in cancer patients, as the lncRNAs play an important regulatory role in the breast cancer-cell survival. Thus, a better understanding of lncRNAs role in the hypoxic conditions of breast cancer is crucial for precise understanding of the tumorigenesis, disease features and poor clinical outcome, especially in highly aggressive breast cancer subtypes (HER2-positive and triple-negative types). Moreover, lncRNAs may represent tumour marker predicting prognosis and therapeutic targets improving precise and personalized therapy for better patient's survival. In this review, we summarize the recent information on lncRNAs in breast cancer with special focus on the hypoxia-responsive lncRNAs and their potential impact on the prognosis, therapy algorithms and individual outcomes. Presented data helps in better understanding of the specific mechanisms predicting new therapeutic agents and strategies for the pharmacological intervention.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kapinova, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kubatka, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zubor, PavolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golubnitschaja, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dankova, ZuzanaUNSPECIFIEDorcid.org/0000-0001-7215-148XUNSPECIFIED
Uramova, SonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilchova, IvanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caprnda, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opatrilova, RadkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richnavsky, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruzliak, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danko, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-194405
DOI: 10.1016/j.biopha.2017.12.104
Journal or Publication Title: Biomed. Pharmacother.
Volume: 99
Page Range: S. 51 - 59
Date: 2018
Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication: ISSY-LES-MOULINEAUX
ISSN: 1950-6007
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EPH RECEPTORS; PATIENT STRATIFICATION; CELL-PROLIFERATION; PROGNOSTIC MARKER; FLAMMER SYNDROME; DOWN-REGULATION; BRCA1 PROMOTER; POOR-PROGNOSIS; UP-REGULATION; LNCRNAMultiple languages
Medicine, Research & Experimental; Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19440

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