Jaeger, Veronika K., Distler, Oliver ORCID: 0000-0002-0546-8310, Maurer, Britta, Czirjak, Laszlo, Lorand, Veronika, Valentini, Gabriele, Vettori, Serena ORCID: 0000-0001-5617-9829, Del Galdo, Francesco, Abignano, Giuseppina ORCID: 0000-0002-1479-0133, Denton, Christopher, Nihtyanova, Svetlana, Allanore, Yannick, Avouac, Jerome, Riemekasten, Gabriele, Siegert, Elise ORCID: 0000-0002-9594-0446, Huscher, Doerte, Matucci-Cerinic, Marco, Guiducci, Serena ORCID: 0000-0003-2722-6475, Frerix, Marc, Tarner, Ingo H., Toth, Beata Garay, Fankhauser, Beat, Umbricht, Jorg, Zakharova, Anastasia, Mihai, Carina, Cozzi, Franco, Yavuz, Sule, Hunzelmann, Nicolas, Rednic, Simona, Vacca, Alessandra, Schmeiser, Tim, Riccieri, Valeria, de la Pena Lefebvre, Paloma Garciae, Gabrielli, Armando, Krummel-Lorenz, Brigitte, Martinovic, Duska, Ancuta, Codrina, Smith, Vanessa, Mueller-Ladner, Ulf and Walker, Ulrich A. (2018). Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group. RHEUMATOLOGY, 57 (3). S. 441 - 451. OXFORD: OXFORD UNIV PRESS. ISSN 1462-0332

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Abstract

The multisystem manifestations of SSc can greatly impact patients' quality of life. The aim of this study was to identify factors associated with disability in SSc. SSc patients from the prospective DeSScipher cohort who had completed the scleroderma health assessment questionnaire (SHAQ), a disability score that combines the health assessment questionnaire and five visual analogue scales, were included in this analysis. The effect of factors possibly associated with disability was analysed with multiple linear regressions. The mean SHAQ and HAQ scores of the 944 patients included were 0.87 (s.d. = 0.66) and 0.92 (s.d. = 0.78); 59% of the patients were in the mild to moderate difficulty SHAQ category (0 a (c) 1/2 SHAQ < 1), 34% in the moderate to severe disability category (1 a (c) 1/2 SHAQ < 2) and 7% in the severe to very severe disability category (2 a (c) 1/2 SHAQ a (c) 1/2 3). The means of the visual analogue scales scores were in order of magnitude: overall disease severity (37 mm), RP (31 mm), pulmonary symptoms (24 mm), gastrointestinal symptoms (20 mm) and digital ulcers (19 mm). In multiple regression, the main factors associated with high SHAQ scores were the presence of dyspnoea [modified New York Heart Association (NYHA) class IV (regression coefficient B = 0.62), modified NYHA class III (B = 0.53) and modified NYHA class II (B = 0.21; all modified NYHA class I)], FM (B = 0.37), muscle weakness (B = 0.27), digital ulcers (B = 0.20) and gastrointestinal symptoms (oesophageal symptoms, B = 0.16; stomach symptoms, B = 0.15; intestinal symptoms, B = 0.15). SSc patients perceive dyspnoea, pain, digital ulcers, muscle weakness and gastrointestinal symptoms as the main factors driving their level of disability, unlike physicians who emphasize objective measures of disability.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jaeger, Veronika K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Distler, OliverUNSPECIFIEDorcid.org/0000-0002-0546-8310UNSPECIFIED
Maurer, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czirjak, LaszloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorand, VeronikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valentini, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vettori, SerenaUNSPECIFIEDorcid.org/0000-0001-5617-9829UNSPECIFIED
Del Galdo, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abignano, GiuseppinaUNSPECIFIEDorcid.org/0000-0002-1479-0133UNSPECIFIED
Denton, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nihtyanova, SvetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allanore, YannickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Avouac, JeromeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemekasten, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siegert, EliseUNSPECIFIEDorcid.org/0000-0002-9594-0446UNSPECIFIED
Huscher, DoerteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matucci-Cerinic, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guiducci, SerenaUNSPECIFIEDorcid.org/0000-0003-2722-6475UNSPECIFIED
Frerix, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tarner, Ingo H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toth, Beata GarayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fankhauser, BeatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Umbricht, JorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zakharova, AnastasiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mihai, CarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cozzi, FrancoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yavuz, SuleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunzelmann, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rednic, SimonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vacca, AlessandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmeiser, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riccieri, ValeriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de la Pena Lefebvre, Paloma GarciaeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gabrielli, ArmandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krummel-Lorenz, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinovic, DuskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ancuta, CodrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Ladner, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, Ulrich A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-194630
DOI: 10.1093/rheumatology/kex182
Journal or Publication Title: RHEUMATOLOGY
Volume: 57
Number: 3
Page Range: S. 441 - 451
Date: 2018
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1462-0332
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEALTH-ASSESSMENT QUESTIONNAIRE; QUALITY-OF-LIFE; EULAR SCLERODERMA TRIALS; RHEUMATOID-ARTHRITIS; CLINICAL-TRIALS; SYMPTOM BURDEN; DISEASE; OUTCOMES; IMPACT; INDEXMultiple languages
RheumatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19463

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