Universität zu Köln

Galvao, Daniel A., Taaffe, Dennis R., Spry, Nigel, Cormie, Prue ORCID: 0000-0002-3446-2698, Joseph, David, Chambers, Suzanne K., Chee, Raphael, Peddle-Mcintyre, Carolyn J., Hart, Nicolas H., Baumann, Freerk T., Denham, James, Baker, Michael ORCID: 0000-0002-0551-4209 and Newton, Robert U. (2018). Exercise Preserves Physical Function in Prostate Cancer Patients with Bone Metastases. Med. Sci. Sports Exerc., 50 (3). S. 393 - 400. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1530-0315

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Abstract

Purpose The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. We examined the efficacy and safety of a modular multimodal exercise program in prostate cancer patients with bone metastases. Methods Between 2012 and 2015, 57 prostate cancer patients (70.0 8.4 yr; body mass index, 28.7 4.0 kgm(2)) with bone metastases (pelvis, 75.4%; femur, 40.4%; rib/thoracic spine, 66.7%; lumbar spine, 43.9%; humerus, 24.6%; other sites, 70.2%) were randomized to multimodal supervised aerobic, resistance, and flexibility exercises undertaken thrice weekly (EX; n = 28) or usual care (CON; n = 29) for 3 months. Physical function subscale of the Medical Outcomes Study Short-Form 36 was the primary end point as an indicator of patient-rated physical functioning. Secondary end points included objective measures of physical function, lower body muscle strength, body composition, and fatigue. Safety was assessed by recording the incidence and severity of any adverse events, skeletal complications, and bone pain throughout the intervention. Results There was a significant difference between groups for self-reported physical functioning (3.2 points; 95% confidence interval, 0.4-6.0 points; P = 0.028) and lower body muscle strength (6.6 kg; 95% confidence interval, 0.6-12.7; P = 0.033) at 3 months favoring EX. However, there was no difference between groups for lean mass (P = 0.584), fat mass (P = 0.598), or fatigue (P = 0.964). There were no exercise-related adverse events or skeletal fractures and no differences in bone pain between EX and CON (P = 0.507). Conclusions Multimodal modular exercise in prostate cancer patients with bone metastases led to self-reported improvements in physical function and objectively measured lower body muscle strength with no skeletal complications or increased bone pain. Trial Registration: ACTRN12611001158954.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galvao, Daniel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Taaffe, Dennis R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spry, Nigel UNSPECIFIED UNSPECIFIED UNSPECIFIED Cormie, Prue UNSPECIFIED orcid.org/0000-0002-3446-2698 UNSPECIFIED Joseph, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Chambers, Suzanne K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chee, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Peddle-Mcintyre, Carolyn J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hart, Nicolas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Freerk T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Denham, James UNSPECIFIED UNSPECIFIED UNSPECIFIED Baker, Michael UNSPECIFIED orcid.org/0000-0002-0551-4209 UNSPECIFIED Newton, Robert U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-195085
DOI:	10.1249/MSS.0000000000001454
Journal or Publication Title:	Med. Sci. Sports Exerc.
Volume:	50
Number:	3
Page Range:	S. 393 - 400
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1530-0315
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; ANDROGEN DEPRIVATION THERAPY; RESISTANCE EXERCISE; AEROBIC EXERCISE; MEN; SUPPRESSION; MEDICINE; MULTICENTER; PERFORMANCE Multiple languages Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19508