Siegel, Corey A., Whitman, Cynthia B., Spiegel, Brennan M. R., Feagan, Brian, Sands, Bruce ORCID: 0000-0001-5762-5042, Loftus, Edward V., Jr., Panaccione, Remo, D'Haens, Geert, Bernstein, Charles N., Gearry, Richard, Ng, Siew C., Mantzaris, Gerassimos J., Sartor, Balfour, Silverberg, Mark S., Riddell, Robert, Koutroubakis, Ioannis E., O'Morain, Colm, Lakatos, Peter L., McGovern, Dermot P. B., Halfvarson, Jonas, Reinisch, Walter, Rogler, Gerhard, Kruis, Wolfgang, Tysk, Curt, Schreiber, Stefan, Danese, Silvio, Sandborn, William, Griffiths, Anne, Moum, Bjorn, Gasche, Christoph ORCID: 0000-0002-3752-6685, Pallone, Francesco, Travis, Simon, Panes, Julian, Colombel, Jean-Frederic, Hanauer, Stephen and Peyrin-Biroulet, Laurent (2018). Development of an index to define overall disease severity in IBD. Gut, 67 (2). S. 244 - 255. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-3288

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Abstract

Background and aim Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were to select the attributes determining overall disease severity, to rank the importance of and to score these individual attributes for both CD and UC. Methods Using a modified Delphi panel, 14 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) selected the most important attributes related to IBD. Eighteen IOIBD members then completed a statistical exercise (conjoint analysis) to create a relative ranking of these attributes. Adjusted utilities were developed by creating proportions for each level within an attribute. Results For CD, 15.8% of overall disease severity was attributed to the presence of mucosal lesions, 10.9% to history of a fistula, 9.7% to history of abscess and 7.4% to history of intestinal resection. For UC, 18.1% of overall disease severity was attributed to mucosal lesions, followed by 14.0% for impact on daily activities, 11.2% C reactive protein and 10.1% for prior experience with biologics. Overall disease severity indices were created on a 100-point scale by applying each attribute's average importance to the adjusted utilities. Conclusions Based on specialist opinion, overall CD severity was associated more with intestinal damage, in contrast to overall UC disease severity, which was more dependent on symptoms and impact on daily life. Once validated, disease severity indices may provide a useful tool for consistent assessment of overall disease severity in patients with IBD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Siegel, Corey A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whitman, Cynthia B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spiegel, Brennan M. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feagan, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sands, BruceUNSPECIFIEDorcid.org/0000-0001-5762-5042UNSPECIFIED
Loftus, Edward V., Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panaccione, RemoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Haens, GeertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernstein, Charles N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gearry, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ng, Siew C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mantzaris, Gerassimos J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sartor, BalfourUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silverberg, Mark S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riddell, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutroubakis, Ioannis E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Morain, ColmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lakatos, Peter L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGovern, Dermot P. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halfvarson, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinisch, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogler, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruis, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tysk, CurtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreiber, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danese, SilvioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sandborn, WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griffiths, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moum, BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gasche, ChristophUNSPECIFIEDorcid.org/0000-0002-3752-6685UNSPECIFIED
Pallone, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Travis, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panes, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colombel, Jean-FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanauer, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peyrin-Biroulet, LaurentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-196465
DOI: 10.1136/gutjnl-2016-312648
Journal or Publication Title: Gut
Volume: 67
Number: 2
Page Range: S. 244 - 255
Date: 2018
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1468-3288
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CROHNS-DISEASE; ULCERATIVE-COLITIS; CONJOINT-ANALYSIS; TREATMENT RISKS; PREFERENCES; MANAGEMENT; PREDICTORS; TOLERANT; THERAPY; DAMAGEMultiple languages
Gastroenterology & HepatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19646

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