Universität zu Köln

Roedel, Franz, Steinhaeuser, Kerstin, Kreis, Nina-Naomi ORCID: 0000-0003-4304-0160, Friemel, Alexandra, Martin, Daniel ORCID: 0000-0002-8674-2683, Wieland, Ulrike, Rave-Fraenk, Margret, Balermpas, Panagiotis ORCID: 0000-0001-5261-6446, Fokas, Emmanouil, Louwen, Frank, Roedel, Claus and Yuan, Juping ORCID: 0000-0003-0694-0565 (2018). Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy. Radiother. Oncol., 126 (2). S. 214 - 222. CLARE: ELSEVIER IRELAND LTD. ISSN 0167-8140

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Abstract

Background: RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA's impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive. Materials and methods: In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS). Results: We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p < 0.0001), whereas in multivariate analyses RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012). Conclusion: These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy. (C) 2017 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 126 (2018) 214-221

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roedel, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinhaeuser, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreis, Nina-Naomi UNSPECIFIED orcid.org/0000-0003-4304-0160 UNSPECIFIED Friemel, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Daniel UNSPECIFIED orcid.org/0000-0002-8674-2683 UNSPECIFIED Wieland, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Rave-Fraenk, Margret UNSPECIFIED UNSPECIFIED UNSPECIFIED Balermpas, Panagiotis UNSPECIFIED orcid.org/0000-0001-5261-6446 UNSPECIFIED Fokas, Emmanouil UNSPECIFIED UNSPECIFIED UNSPECIFIED Louwen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Roedel, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Yuan, Juping UNSPECIFIED orcid.org/0000-0003-0694-0565 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-197003
DOI:	10.1016/j.radonc.2017.10.028
Journal or Publication Title:	Radiother. Oncol.
Volume:	126
Number:	2
Page Range:	S. 214 - 222
Date:	2018
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0167-8140
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN HEPATOCELLULAR-CARCINOMA; HUMAN-PAPILLOMAVIRUS; FOLLOW-UP; CANCER; CHEMORADIATION; SURVIVAL; PATHWAY; HEAD; NECK; HPV Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19700