Universität zu Köln

Wolber, Philipp, Schwarz, David, Stange, Thoralf, Ortmann, Magdalene, Balk, Matthias, Anagiotos, Andreas and Gostian, Antoniu-Oreste (2018). Surgical Treatment for Early Stage Glottic Carcinoma with Involvement of the Anterior Commissure. Otolaryngol. Head Neck Surg., 158 (2). S. 295 - 303. LONDON: SAGE PUBLICATIONS LTD. ISSN 1097-6817

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Abstract

Objective. Assessment of the value of transoral laser microsurgery (TLM) compared with open surgery (OS) for early stage squamous cell carcinoma of the glottic larynx with special regard to involvement of the anterior commissure (AC). Study Design. Case series with chart review. Setting. Tertiary care otolaryngology clinic. Subjects and Methods. Review of clinicopathological data of all patients with previously untreated T1a, T1b, and T2 glottic squamous cell carcinoma of the larynx who were consecutively enrolled over a 10-year period (January 1, 1992, to December 31, 2002). Results. Local recurrence rate was 20.4% (10 of 49) for TLM and 10.7% (3 of 28) for OS. Comparison of the TLM and OS groups regarding local recurrence rates revealed a significant difference only for tumors invading the AC (P = .046). Within the TLM group, tumors with involvement of the AC showed a significantly higher recurrence rate (38.1%; 8 of 21) compared with tumors without involvement of the AC (7.1%; 2 of 28; P = .008). In the OS group, involvement of the AC revealed no significant difference (P = .45). The overall survival in both groups was comparable in both groups (TLM, 93.9%; OS, 89.3%; P = .47). Conclusion. TLM and OS are equally effective surgical treatments for early stage glottic cancer without involvement of the AC, with selection of treatment based on pretreatment endoscopy. However, TLM is associated with less morbidity. In case of invasion of the AC, OS yields lower recurrence rates.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolber, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Stange, Thoralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortmann, Magdalene UNSPECIFIED UNSPECIFIED UNSPECIFIED Balk, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Anagiotos, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gostian, Antoniu-Oreste UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-197924
DOI:	10.1177/0194599817728476
Journal or Publication Title:	Otolaryngol. Head Neck Surg.
Volume:	158
Number:	2
Page Range:	S. 295 - 303
Date:	2018
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1097-6817
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; LASER-SURGERY; PARTIAL LARYNGECTOMY; CO2-LASER SURGERY; SALVAGE SURGERY; CANCER; LARYNX; RADIOTHERAPY; MICROSURGERY; IMPACT Multiple languages Otorhinolaryngology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19792