Universität zu Köln

Stahl, Mirjam, Holfelder, Christian, Kneppo, Carolin, Kieser, Meinhard, Kasperk, Christian, Schoenau, Eckhard, Sommerburg, Olaf and Toenshoff, Burkhard (2018). FS7BJ Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis. J. Cyst. Fibros, 17 (1). S. 114 - 121. AMSTERDAM: ELSEVIER. ISSN 1873-5010

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Abstract

Background: The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. Methods: In a cross-sectional study of 43 CF patients (age, 17.8 +/- 6.2 years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. Results: The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25 years was reduced to 39.8% compared to 84.6% in controls (P < 0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). Conclusions: Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients. (C) 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stahl, Mirjam UNSPECIFIED UNSPECIFIED UNSPECIFIED Holfelder, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kneppo, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kieser, Meinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasperk, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommerburg, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Toenshoff, Burkhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-199256
DOI:	10.1016/j.jcf.2016.06.004
Journal or Publication Title:	J. Cyst. Fibros
Volume:	17
Number:	1
Page Range:	S. 114 - 121
Date:	2018
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-5010
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOLID-ORGAN TRANSPLANTATION; VERTEBRAL FRACTURES; PROXIMAL RADIUS; MINERAL DENSITY; YOUNG-ADULTS; CHILDREN; CHILDHOOD; STRENGTH; PREDICTORS; KYPHOSIS Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19925