Universität zu Köln

Steigerwald, Frank ORCID: 0000-0002-8305-1684, Timmermann, Lars, Kuehn, Andrea, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Reich, Martin M., Kirsch, Anna Dalal, Barbe, Michael Thomas, Visser-Vandewalle, Veerle, Huebl, Julius, van Riesen, Christoph, Groiss, Stefan Jun, Moldovan, Alexia-Sabine, Lin, Sherry, Carcieri, Stephen, Manola, Ljubomir and Volkmann, Jens (2018). Pulse Duration Settings in Subthalamic Stimulation for Parkinson's Disease. Mov. Disord., 33 (1). S. 165 - 170. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background: Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations. Methods: A total of 15 patients were programmed using a pulse width of 30 mu s (test) or 60 mu s (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome). The therapeutic window was the difference between patients' efficacy and side effect thresholds. Results: The therapeutic window was significantly larger at 30 mu s than 60 mu s (P=.0009) and the efficacy (UPDRS III score) was noninferior (P=.00008). Interpretation: Subthalamic neurostimulation at 30 mu s versus 60 mu s pulse width is equally effective on PD motor signs, is more energy efficient, and has less likelihood of stimulation-related side effects. (c) 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Steigerwald, Frank UNSPECIFIED orcid.org/0000-0002-8305-1684 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuehn, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnitzler, Alfons UNSPECIFIED orcid.org/0000-0002-6414-7939 UNSPECIFIED Reich, Martin M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirsch, Anna Dalal UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebl, Julius UNSPECIFIED UNSPECIFIED UNSPECIFIED van Riesen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Groiss, Stefan Jun UNSPECIFIED UNSPECIFIED UNSPECIFIED Moldovan, Alexia-Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Sherry UNSPECIFIED UNSPECIFIED UNSPECIFIED Carcieri, Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Manola, Ljubomir UNSPECIFIED UNSPECIFIED UNSPECIFIED Volkmann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200797
DOI:	10.1002/mds.27238
Journal or Publication Title:	Mov. Disord.
Volume:	33
Number:	1
Page Range:	S. 165 - 170
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20079