Universität zu Köln

Herb, Marc ORCID: 0000-0002-7533-0288, Gluschko, Alexander and Schramm, Michael (2018). LC3-associated phagocytosis initiated by integrin ITGAM-ITGB2/Mac-1 enhances immunity to Listeria monocytogenes. Autophagy, 14 (8). S. 1462 - 1465. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1554-8635

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Abstract

The macroautophagic/autophagic machinery cannot only target cell-endogenous components but also intracellular pathogenic bacteria such as Listeria monocytogenes. Listeria are targeted both by canonical autophagy and by a noncanonical form of autophagy referred to as LC3-associated phagocytosis (LAP). The molecular mechanisms involved and whether these processes contribute to anti-listerial immunity or rather provide Listeria with a replicative niche for persistent infection, however, remained unknown. Recently, using an in vivo mouse infection model, we have been able to demonstrate that Listeria in tissue macrophages are targeted exclusively by LAP. Furthermore, our data show that LAP is required for killing of Listeria by macrophages and thereby contributes to anti-listerial immunity of mice, whereas canonical autophagy is completely dispensable. Moreover, we have elucidated the molecular mechanisms that trigger LAP of Listeria and identified the integrin ITGAM-ITGB2/Mac-1/CR3/integrin (M)ss(2) as the receptor that initiates LAP in response to Listeria infection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herb, Marc UNSPECIFIED orcid.org/0000-0002-7533-0288 UNSPECIFIED Gluschko, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schramm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202171
DOI:	10.1080/15548627.2018.1475816
Journal or Publication Title:	Autophagy
Volume:	14
Number:	8
Page Range:	S. 1462 - 1465
Date:	2018
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1554-8635
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20217