Universität zu Köln

Mohamed, Mohamed Shehata Ali (2018). Multiple Sclerosis Under Attack; Shehata's Therapy. Turk. J. Immunol., 6 (1). S. 37 - 47. ISTANBUL: TURKISH SOC IMMUNOLOGY. ISSN 2147-8325

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Abstract

Multiple sclerosis is an autoimmune disease characterized by inflammatory demylination of the nerves in the central nervous system (brain and spinal cord). Depending on the attacked sites, the disease manifestations vary from limited sensory and/or motoric defuits to wide spread neurological and cognitive deficits. Similar to other autoimmune neurological and non-neurological diseases, the available therapeutic strategies rely on the pharmacological modulation of the immunity, which could be associated with significant side effects. In this paper, the light will be shed on another innovative therapeutic strategy that rely on the biological modulation ot the immune responses, together with the inhibition ol the recruitment of the immune cells into the central nervous system after distortion of (he blood brain barrier, as well as the enhancement ol the regenerative ability towards the restoration of efficient blood brain barrier and the regenerative recovery of the neurological deficits.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mohamed, Mohamed Shehata Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202251
DOI:	10.25002/tji.2018.774
Journal or Publication Title:	Turk. J. Immunol.
Volume:	6
Number:	1
Page Range:	S. 37 - 47
Date:	2018
Publisher:	TURKISH SOC IMMUNOLOGY
Place of Publication:	ISTANBUL
ISSN:	2147-8325
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLACEBO-CONTROLLED TRIAL; MESENCHYMAL STEM-CELLS; DOUBLE-BLIND; CONTROLLED PHASE-3; GLATIRAMER ACETATE; INTRAMUSCULAR INTERFERON; NEUTROPHIL ADHESION; ORAL TERIFLUNOMIDE; PLASMA-EXCHANGE; IN-VITRO Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20225