Gessner, Isabel ORCID: 0000-0001-9674-161X, Krakor, Eva, Jurewicz, Anna, Wulff, Veronika, Kling, Lasse ORCID: 0000-0003-1246-8228, Christiansen, Silke, Brodusch, Nicolas, Gauvin, Raynald, Wortmann, Laura, Wolke, Martina, Plum, Georg, Schauss, Astrid, Krautwurst, John, Ruschewitz, Uwe ORCID: 0000-0002-6511-6894, Ilyas, Shaista and Mathur, Sanjay (2018). Hollow silica capsules for amphiphilic transport and sustained delivery of antibiotic and anticancer drugs. RSC Adv., 8 (44). S. 24883 - 24893. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 2046-2069

Full text not available from this repository.

Abstract

Hollow mesoporous silica capsules (HMSC) are potential drug transport vehicles due to their biocompatibility, high loading capacity and sufficient stability in biological milieu. Herein, we report the synthesis of ellipsoid-shaped HMSC (aspect ratio approximate to 2) performed using hematite particles as solid templates that were coated with a conformal silica shell through cross-condensation reactions. For obtaining hollow silica capsules, the iron oxide core was removed by acidic leaching. Gas sorption studies on HMSC revealed mesoscopic pores (main pore width approximate to 38 angstrom) and a high surface area of 308.8 m(2) g(-1). Cell uptake of dye-labeled HMSC was confirmed by incubating them with human cervical cancer (HeLa) cells and analyzing the internalization through confocal microscopy. The amphiphilic nature of HMSC for drug delivery applications was tested by loading antibiotic (ciprofloxacin) and anticancer (curcumin) compounds as model drugs for hydrophilic and hydrophobic therapeutics, respectively. The versatility of HMSC in transporting hydrophilic as well as hydrophobic drugs and a pH dependent drug release over several days under physiological conditions was demonstrated in both cases by UV-vis spectroscopy. Ciprofloxacin-loaded HMSC were additionally evaluated towards Gram negative (E. coli) bacteria and demonstrated their efficacy even at low concentrations (10 g ml(-1)) in inhibiting complete bacterial growth over 18 hours.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gessner, IsabelUNSPECIFIEDorcid.org/0000-0001-9674-161XUNSPECIFIED
Krakor, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jurewicz, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wulff, VeronikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kling, LasseUNSPECIFIEDorcid.org/0000-0003-1246-8228UNSPECIFIED
Christiansen, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brodusch, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gauvin, RaynaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wortmann, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolke, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plum, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schauss, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krautwurst, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschewitz, UweUNSPECIFIEDorcid.org/0000-0002-6511-6894UNSPECIFIED
Ilyas, ShaistaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathur, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-202326
DOI: 10.1039/c8ra03716g
Journal or Publication Title: RSC Adv.
Volume: 8
Number: 44
Page Range: S. 24883 - 24893
Date: 2018
Publisher: ROYAL SOC CHEMISTRY
Place of Publication: CAMBRIDGE
ISSN: 2046-2069
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MESOPOROUS SILICA; NANOPARTICLES; RELEASE; FABRICATION; ADSORPTIONMultiple languages
Chemistry, MultidisciplinaryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20232

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item