Universität zu Köln

Rink, Svenja, Bendella, Habib, Alsolivany, Kurdin, Meyer, Carolin, Woehler, Aliona, Jansen, Ramona, Isik, Zeynep, Stein, Gregor, Wennmachers, Sina, Nakamura, Makoto and Angelov, Doychin N. (2018). Constitutively reduced sensory capacity promotes better recovery after spinal cord-injury (SCI) in blind rats of the dystrophic RCS strain. Restor. Neurol. Neurosci., 36 (3). S. 397 - 417. AMSTERDAM: IOS PRESS. ISSN 1878-3627

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Abstract

Background: We compared functional, electrophysiological and morphological parameters after SCI in two groups of rats Sprague Dawley (SD) rats with normal vision and blind rats from a SD-substrain Royal College of Surgeons (SD/RCS) who lose their photoreceptor cells after birth due to a genetic defect in the retinal pigment epithelium. For these animals skin-, intramuscular-, and tendon receptors are major available means to resolve spatial information. Objective: The purpose of this study was to check whether increased sensitivity in SD/RCS rats would promote an improved recovery after SCI. Methods: All rats were subjected to severe compression of the spinal cord at vertebra Th8, spinal cord segment Th10. Recovery of locomotion was analyzed at 1, 3, 6, 9, and 12 weeks after SCI using video recordings of beam walking and inclined ladder climbing. Five functional parameters were studied: foot-stepping angle (FSA), rump-height index (RHI) estimating paw placement and body weight support, respectively, number of correct ladder steps (CLS) assessing skilled hindlimb movements, the BBB-locomotor score and an established urinary bladder score (BS). Sensitivity tests were followed by electrophysiological measurement of M- and H-wave amplitudes from contractions of the plantar musculature after stimulation of the tibial nerve. The closing morphological measurements included lesion volume and expression of astro- and microglia below the lesion. Results: Numerical assessments of BBB, FSA, BS, lesion volume and GFAP-expression revealed no significant differences between both strains. However, compared to SD-rats, the blind SD/RCS animals significantly improved RHI and CLS by 6 - 12 weeks after SCI. To our surprise the withdrawal latencies in the blind SD/RCS rats were longer and the amplitudes of M- and H-waves lower. The expression of IBA1-immunoreactivity in the lumbar enlargement was lower than in the SD-animals. Conclusion: The longer withdrawal latencies suggest a decreased sensitivity in the blind SD/RCS rats, which promotes better recovery after SCI. In this way our results provide indirect support to earlier work showing, that hypersensitivity and chronic pain after contusive SCI impair the recovery of locomotor function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rink, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Alsolivany, Kurdin UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Woehler, Aliona UNSPECIFIED UNSPECIFIED UNSPECIFIED Jansen, Ramona UNSPECIFIED UNSPECIFIED UNSPECIFIED Isik, Zeynep UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Wennmachers, Sina UNSPECIFIED UNSPECIFIED UNSPECIFIED Nakamura, Makoto UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202874
DOI:	10.3233/RNN-170789
Journal or Publication Title:	Restor. Neurol. Neurosci.
Volume:	36
Number:	3
Page Range:	S. 397 - 417
Date:	2018
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1878-3627
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INHERITED RETINAL DYSTROPHY; FACIAL-NERVE TRANSECTION; FUNCTIONAL RECOVERY; THERMAL NOCICEPTION; NEURAL PLASTICITY; REFLEX RESPONSES; IMPAIRS RECOVERY; NEUROPATHIC PAIN; MOTOR RECOVERY; ADULT-RAT Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20287