Universität zu Köln

Grosheva, Maria ORCID: 0000-0002-5985-468X, Rink, Svenja, Jansen, Ramona, Bendella, Habib, Pavlov, Stoyan P., Sarikcioglu, Levent, Angelov, Doychin N. and Dunlop, Sarah A. (2018). EARLY AND CONTINUED MANUAL STIMULATION IS REQUIRED FOR LONG-TERM RECOVERY AFTER FACIAL NERVE INJURY. Muscle Nerve, 57 (1). S. 100 - 107. HOBOKEN: WILEY. ISSN 1097-4598

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Abstract

Introduction: We previously have shown that manual stimulation (MS) of vibrissal muscles for 2 months after facial nerve injury in rats improves whisking and reduces motor end plate polyinnervation. Here, we seek to determine whether discontinuing or delaying MS after facial-facial anastomosis (FFA) leads to similar results. Methods: Rats were subjected to FFA and received MS for (1) 4 months (early and continued), (2) the first but not the last 2 months (discontinued), or (3) the last 2 months (delayed). Intact animals and those not receiving MS (no MS) were also examined. Results: Early and continued MS restored whisking amplitude to 438, a value significantly higher compared with the discontinued, delayed, and no MS groups (328, 248, and 108, respectively). Motor end plate polyinnervation occurred in all experimental groups but was significantly higher in the delayed group. Discussion: Early and continued MS results in better recovery than when it is either discontinued or delayed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grosheva, Maria UNSPECIFIED orcid.org/0000-0002-5985-468X UNSPECIFIED Rink, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Jansen, Ramona UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavlov, Stoyan P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarikcioglu, Levent UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunlop, Sarah A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-205131
DOI:	10.1002/mus.25613
Journal or Publication Title:	Muscle Nerve
Volume:	57
Number:	1
Page Range:	S. 100 - 107
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-4598
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FIBER-TYPE DISPROPORTION; CONGENITAL MYOPATHY; TPM2 GENE; MUTATIONS; TROPOMYOSIN; PHENOTYPE Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20513