Grosheva, Maria ORCID: 0000-0002-5985-468X, Rink, Svenja, Jansen, Ramona, Bendella, Habib, Pavlov, Stoyan P., Sarikcioglu, Levent, Angelov, Doychin N. and Dunlop, Sarah A. (2018). EARLY AND CONTINUED MANUAL STIMULATION IS REQUIRED FOR LONG-TERM RECOVERY AFTER FACIAL NERVE INJURY. Muscle Nerve, 57 (1). S. 100 - 107. HOBOKEN: WILEY. ISSN 1097-4598

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Abstract

Introduction: We previously have shown that manual stimulation (MS) of vibrissal muscles for 2 months after facial nerve injury in rats improves whisking and reduces motor end plate polyinnervation. Here, we seek to determine whether discontinuing or delaying MS after facial-facial anastomosis (FFA) leads to similar results. Methods: Rats were subjected to FFA and received MS for (1) 4 months (early and continued), (2) the first but not the last 2 months (discontinued), or (3) the last 2 months (delayed). Intact animals and those not receiving MS (no MS) were also examined. Results: Early and continued MS restored whisking amplitude to 438, a value significantly higher compared with the discontinued, delayed, and no MS groups (328, 248, and 108, respectively). Motor end plate polyinnervation occurred in all experimental groups but was significantly higher in the delayed group. Discussion: Early and continued MS results in better recovery than when it is either discontinued or delayed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Grosheva, MariaUNSPECIFIEDorcid.org/0000-0002-5985-468XUNSPECIFIED
Rink, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, RamonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bendella, HabibUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pavlov, Stoyan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarikcioglu, LeventUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angelov, Doychin N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunlop, Sarah A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-205131
DOI: 10.1002/mus.25613
Journal or Publication Title: Muscle Nerve
Volume: 57
Number: 1
Page Range: S. 100 - 107
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-4598
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FIBER-TYPE DISPROPORTION; CONGENITAL MYOPATHY; TPM2 GENE; MUTATIONS; TROPOMYOSIN; PHENOTYPEMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20513

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