Universität zu Köln

Bauer, Britta, Goederz, Anna-Lena, Braumueller, Heidi, Neudoerfl, Joerg Martin, Roecken, Martin, Wieder, Thomas and Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 (2017). Methyl Fumarate-Derived Iron Carbonyl Complexes (FumET-CORMs) as Powerful Anti-inflammatory Agents. ChemMedChem, 12 (23). S. 1927 - 1931. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1860-7187

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Abstract

Autoimmune diseases are characterized by dendritic cell (DC)-driven activation of pro-inflammatory Tcell responses. Therapeutic options for these severe diseases comprise small molecules such as dimethyl fumarate, or gasotransmitters such as CO. Herein we describe the synthesis of bifunctional enzyme-triggered CO-releasing molecules (ET-CORMs) that allow the simultaneous intracellular release of both CO and methyl fumarate. Using bone-marrow-derived DCs the impressive therapeutic potential of these methyl fumarate-derived compounds (FumET-CORMs) is demonstrated by strong inhibition of lipopolysaccharide-induced pro-inflammatory signaling pathways and blockade of downstream interleukin-12 or -23 production. The data also show that FumET-CORMs are able to transform DCs into an anti-inflammatory phenotype. Thus, these novel compounds have great clinical potential, for example, for the treatment of psoriasis or other inflammatory conditions of the skin.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bauer, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Goederz, Anna-Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Braumueller, Heidi UNSPECIFIED UNSPECIFIED UNSPECIFIED Neudoerfl, Joerg Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Roecken, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieder, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Guenther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-208108
DOI:	10.1002/cmdc.201700488
Journal or Publication Title:	ChemMedChem
Volume:	12
Number:	23
Page Range:	S. 1927 - 1931
Date:	2017
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1860-7187
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CO-RELEASING MOLECULES; REMITTING MULTIPLE-SCLEROSIS; TRICARBONYL COMPLEXES; DOUBLE-BLIND; ET-CORMS; MONOXIDE; MULTICENTER; PSORIASIS; SAFETY; NRF2 Multiple languages Chemistry, Medicinal; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20810