Universität zu Köln

Morfeld, Peter, Gross, Juliane Valerie, Erren, Thomas C., Noll, Birgit, Yong, Mei, Kennedy, Katrin J., Esmen, Nurtan A., Zimmerman, Sarah D., Buchanich, Jeanine M. and Marsh, Gary M. (2017). Mortality Among Hardmetal Production Workers German Historical Cohort Study. J. Occup. Environ. Med., 59 (12). S. E288 - 9. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-5948

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Abstract

Objective: The aim of this study was to investigate a cohort in German hardmetal industry, especially relationship between exposures to cobalt, with and without tungsten, and risks of total and cause-specific mortality. Methods: The cohort comprises blue-collar workers at three German plants who were employed in hardmetal processing. Individual cumulative exposures and long-term average concentrations were estimated for cobalt, nickel, tungsten, respirable, and inhalable dust. Standardized mortality ratios (SMRs) were calculated for external comparisons. Time-dependent multi-variable Cox models were performed for internal analyses. Results: Elevated SMRs were found for all-cause, heart diseases, and nonmalignant respiratory diseases mortality, but not for lung cancer. Internal analyses did not show increased risks for any endpoints, and no exposure-response relationship was indicated. Conclusions: This study does not provide evidence for elevated lung cancer risks. Methodologic limitations, incomplete ascertainment of death causes in particular, impede conclusions about exposure effects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Morfeld, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Gross, Juliane Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED Erren, Thomas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Noll, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Yong, Mei UNSPECIFIED UNSPECIFIED UNSPECIFIED Kennedy, Katrin J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Esmen, Nurtan A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmerman, Sarah D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchanich, Jeanine M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marsh, Gary M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-208584
DOI:	10.1097/JOM.0000000000001061
Journal or Publication Title:	J. Occup. Environ. Med.
Volume:	59
Number:	12
Page Range:	S. E288 - 9
Date:	2017
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-5948
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LUNG-CANCER MORTALITY; HARD-METAL WORKERS; EXPOSURE-ASSESSMENT; INDUSTRY Multiple languages Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20858