Graf, Jonas, Leussink, Verena I., Dehmel, Thomas, Ringelstein, Marius, Goebels, Norbert, Adams, Ortwin, MacKenzie, Colin R., Warnke, Clemens, Feldt, Torsten, Lammerskitten, Anna, Klotz, Luisa, Meuth, Sven, Wiendl, Heinz ORCID: 0000-0003-4310-3432, Hartung, Hans-Peter, Aktas, Orhan ORCID: 0000-0002-2020-9210 and Albrecht, Philipp (2017). Infectious risk stratification in multiple sclerosis patients receiving immunotherapy. Ann. Clin. Transl. Neurol., 4 (12). S. 909 - 915. HOBOKEN: WILEY. ISSN 2328-9503

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Abstract

The increasing number of potent treatments for multiple sclerosis warrants screening for infections. To investigate the prevalence of infections in two independent German patient cohorts with multiple sclerosis/neuromyelitis optica spectrum disorders (NMOSD), we performed a retrospective chart review study of multiple sclerosis/NMOSD patients who underwent testing for infections between 2014 and 2016. We show that 6 out of 80 tested patients (Dusseldorf cohort) and 2 out of 97 tested patients (Munster cohort) had a latent tuberculosis infection; total 3.95%, 95% CI: 2-8%. Our findings suggest that latent tuberculosis infection is frequent (>1%). Screening should be performed before embarking on immunomodulatory therapies to allow treatment and mitigation of the risk of a reactivation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Graf, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leussink, Verena I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dehmel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ringelstein, MariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goebels, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adams, OrtwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacKenzie, Colin R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feldt, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammerskitten, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klotz, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meuth, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiendl, HeinzUNSPECIFIEDorcid.org/0000-0003-4310-3432UNSPECIFIED
Hartung, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aktas, OrhanUNSPECIFIEDorcid.org/0000-0002-2020-9210UNSPECIFIED
Albrecht, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-208844
DOI: 10.1002/acn3.491
Journal or Publication Title: Ann. Clin. Transl. Neurol.
Volume: 4
Number: 12
Page Range: S. 909 - 915
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2328-9503
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CONTROLLED PHASE-3 TRIAL; LATENT TUBERCULOSIS; RITUXIMAB; OCRELIZUMAB; ALEMTUZUMAB; THERAPY; PLACEBOMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20884

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