Universität zu Köln

Goranci-Buzhala, Gladiola, Gabriel, Elke, Mariappan, Aruljothi and Gopalakrishnan, Jay (2017). Losers of Primary Cilia Gain the Benefit of survival. Cancer Discov., 7 (12). S. 1374 - 1376. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2159-8290

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Abstract

In this issue, Zhao and colleagues demonstrate that loss of primary cilia in medulloblastoma cells confers resistance to the Smoothened (SMO) inhibitor sonidegib. When treated with sonidegib, medulloblastoma cells lost their cilia and gained resistance. Surprisingly, loss of cilia is associated with recurrent mutations in ciliogenesis genes that are eventually able to drive drug resistance. These findings uncover a previously unknown mechanism of cancer cells in gaining a persister-like state against anticancer agents at the expense of losing primary cilia. (C) 2017 AACR.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goranci-Buzhala, Gladiola UNSPECIFIED UNSPECIFIED UNSPECIFIED Gabriel, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Mariappan, Aruljothi UNSPECIFIED UNSPECIFIED UNSPECIFIED Gopalakrishnan, Jay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-209415
DOI:	10.1158/2159-8290.CD-17-1085
Journal or Publication Title:	Cancer Discov.
Volume:	7
Number:	12
Page Range:	S. 1374 - 1376
Date:	2017
Publisher:	AMER ASSOC CANCER RESEARCH
Place of Publication:	PHILADELPHIA
ISSN:	2159-8290
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20941