Sud, Amit ORCID: 0000-0002-6133-0164, Thomsen, Hauke ORCID: 0000-0001-5951-3116, Law, Philip J., Foersti, Asta, da Silva Filho, Miguel Inacio, Holroyd, Amy, Broderick, Peter ORCID: 0000-0002-8348-5829, Orlando, Giulia, Lenive, Oleg, Wright, Lauren, Cooke, Rosie, Easton, Douglas, Pharoah, Paul ORCID: 0000-0001-8494-732X, Dunning, Alison, Peto, Julian, Canzian, Federico ORCID: 0000-0002-4261-4583, Eeles, Rosalind ORCID: 0000-0002-3698-6241, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora ORCID: 0000-0003-0843-2468, Hoffmann, Per, Noethen, Markus M., Joeckel, Karl-Heinz, von Strandmann, Elke Pogge, Lightfoot, Tracy, Kane, Eleanor, Roman, Eve, Lake, Annette, Montgomery, Dorothy, Jarrett, Ruth F., Swerdlow, Anthony J., Engert, Andreas, Orr, Nick, Hemminki, Kari and Houlston, Richard S. (2017). Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. Nat. Commun., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 x 10(-8)) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 x 10(-17)), 6q23.3 (rs6928977, P = 4.62 x 10(-11)), 10p14 (rs3781093, P = 9.49 x 10(-13)), 13q34 (rs112998813, P = 4.58 x 10(-8)) and 16p13.13 (rs34972832, P= 2.12 x 10(-8)). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1* 03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLADRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sud, AmitUNSPECIFIEDorcid.org/0000-0002-6133-0164UNSPECIFIED
Thomsen, HaukeUNSPECIFIEDorcid.org/0000-0001-5951-3116UNSPECIFIED
Law, Philip J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foersti, AstaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
da Silva Filho, Miguel InacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holroyd, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broderick, PeterUNSPECIFIEDorcid.org/0000-0002-8348-5829UNSPECIFIED
Orlando, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenive, OlegUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wright, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cooke, RosieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, DouglasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, PaulUNSPECIFIEDorcid.org/0000-0001-8494-732XUNSPECIFIED
Dunning, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canzian, FedericoUNSPECIFIEDorcid.org/0000-0002-4261-4583UNSPECIFIED
Eeles, RosalindUNSPECIFIEDorcid.org/0000-0002-3698-6241UNSPECIFIED
Kote-Jarai, ZSofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muir, KennethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pashayan, NoraUNSPECIFIEDorcid.org/0000-0003-0843-2468UNSPECIFIED
Hoffmann, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joeckel, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Strandmann, Elke PoggeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lightfoot, TracyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kane, EleanorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roman, EveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lake, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, DorothyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarrett, Ruth F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swerdlow, Anthony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orr, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemminki, KariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houlston, Richard S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-209492
DOI: 10.1038/s41467-017-00320-1
Journal or Publication Title: Nat. Commun.
Volume: 8
Date: 2017
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REED-STERNBERG CELLS; CAPTURE HI-C; GENE-EXPRESSION; RISK LOCI; TRANSCRIPTION FACTORS; MULTIPLE-SCLEROSIS; DOWN-REGULATION; EBV STATUS; B-CELLS; METAANALYSISMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20949

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