Iliadis, Christos, Lee, Samuel, Kuhr, Kathrin, Metze, Clemens, Matzik, Anna-Sophie, Michels, Guido, Rudolph, Volker, Baldus, Stephan and Pfister, Roman (2017). Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review. Clin. Res. Cardiol., 106 (12). S. 1005 - 1018. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692
Full text not available from this repository.Abstract
Estimating the quantitative effect of transcatheter mitral valve repair on functional parameters and quality of life is important for individual treatment decision-making. We combined data from a prospective monocentric cohort study (N = 215) with data from a systematic literature review (PubMed search term mitraclip, till 30.04.2016) on patients undergoing MitraClip with at least mortality after discharge reported as an outcome. Effects on functional parameters were reported as range of mean change. 36 observational studies and 1 randomized controlled trial were identified. Due to substantial heterogeneity of effect estimates (I (2)-heterogeneity > 75%) and inadequate quality of studies with a lack of comparison group in 97.4% and lack of an independent assessment of outcomes in 86.8%, no pooled estimates were calculated. All studies reported improvements of mean New York Heart Association (NYHA) class (0.5-1.9 classes), Short-Form (SF)-12/36 scores (4.4-9.2 for physical component score, 2.6-8.9 for mental component score), 6-min walk distance [(6MWD) 2-336 m] and Minnesota Living with Heart failure questionnaire (MLWHFQ) score (-7 to -18 points), with improvements regarded as clinically relevant in 20 of 29 studies for NYHA class, in all of 7 studies for SF12/36, in 9 of 15 studies for 6MWD and in all of 8 studies for MLWHFQ. MitraClip therapy provides improvements in physical capacity, physical and mental functioning and disease-specific quality of life in the majority of patients. However, more comparative and high-quality studies are required for understanding the heterogeneity of results, which is crucial for optimal patient selection.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-209726 | ||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1007/s00392-017-1150-x | ||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Clin. Res. Cardiol. | ||||||||||||||||||||||||||||||||||||||||
Volume: | 106 | ||||||||||||||||||||||||||||||||||||||||
Number: | 12 | ||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 1005 - 1018 | ||||||||||||||||||||||||||||||||||||||||
Date: | 2017 | ||||||||||||||||||||||||||||||||||||||||
Publisher: | SPRINGER HEIDELBERG | ||||||||||||||||||||||||||||||||||||||||
Place of Publication: | HEIDELBERG | ||||||||||||||||||||||||||||||||||||||||
ISSN: | 1861-0692 | ||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/20972 |
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