Universität zu Köln

Yeoa, Sin Yuin, Kim, Young-sun, Lim, Hyo Keun, Rhim, Hyunchul, Jung, Sin-Ho and Hwang, Na Young (2017). Uterine fibroids: Influence of T2-Rim sign on immediate therapeutic responses to magnetic resonance imaging-guided high-intensity focused ultrasound ablation. Eur. J. Radiol., 97. S. 21 - 31. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7727

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Abstract

Objectives: To investigate the influence of a high-signal-intensity peripheral rim on T2-weighted MR images (i.e., T2-rim sign) on the immediate therapeutic responses of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids. Methods: This retrospective study was approved by the institutional review board, and patient informed consent was obtained for MR-HIFU ablation. In total, 196 fibroids (diameter 6.2 +/- 2.6 cm) in 123 women (age 43.4 +/- 5.0 years) who underwent MR-HIFU ablation from January 2013 to April 2016 were included. The effects of a T2-rim sign on the immediate therapeutic responses (non-perfused volume [NPV] ratio, ablation efficiency [NPV/treatment cell volume], ablation quality [grade 1-5, poor to excellent]) were investigated with univariable and multivariable analyses using generalized estimating equation (GEE) analysis. In multivariable analysis, T2 signal intensity ratio of fibroids-to-skeletal muscle, relative peak enhancement of fibroids, and subcutaneous fat thickness were also considered. Results: The presence of a T2-rim sign significantly lowered the NPV ratio (54.0 +/- 28.0% vs. 83.7 +/- 17.7%), ablation efficiency (0.6 +/- 0.5 vs. 1.3 +/- 0.6), ablation quality (3.1 +/- 1.2 vs. 4.2 +/- 0.8), (P < 0.0001). GEE analysis showed that the presence of a T2-rim sign was independently significant for ablation efficiency and ablation quality (P < 0.05). Conclusion: Uterine fibroids with a T2-rim sign showed significantly poorer immediate therapeutic responses to MR-HIFU ablation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yeoa, Sin Yuin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Young-sun UNSPECIFIED UNSPECIFIED UNSPECIFIED Lim, Hyo Keun UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhim, Hyunchul UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Sin-Ho UNSPECIFIED UNSPECIFIED UNSPECIFIED Hwang, Na Young UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210470
DOI:	10.1016/j.ejrad.2017.10.006
Journal or Publication Title:	Eur. J. Radiol.
Volume:	97
Page Range:	S. 21 - 31
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7727
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL-OUTCOMES; SURGERY; LEIOMYOMAS; FEASIBILITY; PREDICTORS; SUCCESS; MYOMAS; SAFETY; TUMORS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21047