Universität zu Köln

Roscher, K. A., Failing, K., Schenk, I. and Moritz, A. (2017). Suspected aspirin resistance in individual healthy adult warmblood horses. J. Vet. Pharmacol. Ther., 40 (6). S. e16 - 7. HOBOKEN: WILEY. ISSN 1365-2885

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Abstract

The reasons for this prospective experimental study were to determine a dosing scheme with loading and maintenance dose of aspirin inducing inhibition of platelet function measured by whole blood impedance aggregometry. Ten horses received aspirin orally in the morning with one loading dose of 4.7-5mg/kg and maintenance doses of 1-1.3mg/kg daily the following 4days. Aggregometries (COLtest, ASPItest, ADPtest) and serum salicylic acid were measured. ASPItest showed significant difference in inhibition at 24 and 48hr (p<.05) and 96hr (p<.01). Significant change for ADPtest and COLtest couldn't be detected. Serum salicylic acid concentrations were significantly (p<.01) increased at 6 and 12hr. Despite this, three horses failed any inhibitory effect of platelet function, suspecting an aspirin resistance. Regarding the other seven horses platelet aggregation induced by ASPItest was reduced between 37% and 100% from baseline at 6 and 12hr and between 0 and 98% during the next 4days. Correlations of serum concentration of salicylic acid and aggregometries couldn't be detected. It can be presumed that equine platelets are less susceptible to aspirin what may compromise eventually the anticoagulatory effects and efficacy in preventing and treating diseases with increased platelet activation as endotoxaemia or laminitis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roscher, K. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Failing, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moritz, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210613
DOI:	10.1111/jvp.12408
Journal or Publication Title:	J. Vet. Pharmacol. Ther.
Volume:	40
Number:	6
Page Range:	S. e16 - 7
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2885
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIGHT TRANSMISSION AGGREGOMETRY; TEMPLATE BLEEDING-TIME; PLATELET-AGGREGATION; IMPEDANCE AGGREGOMETER; THROMBOXANE PRODUCTION; CLOPIDOGREL; ACTIVATION; INHIBITION; GENERATION; LAMINITIS Multiple languages Pharmacology & Pharmacy; Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21061