Augsburger, Daniela, Nelson, Peter J., Kalinski, Thomas, Udelnow, Andrej, Knoesel, Thomas, Hofstetter, Monika, Qin, Ji Wei, Wang, Yan, Sen Gupta, Arvid, Bonifatius, Susanne, Li, Minglun, Bruns, Christiane J. and Zhao, Yue (2017). Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies. Oncotarget, 8 (61). S. 104638 - 104654. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

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Abstract

Adult-type fibrosarcoma is a rare and highly aggressive subtype of soft tissue sarcomas. Due to the existence of other spindle-cell shaped sarcomas, its diagnosis is always one of exclusion. The likelihood of misdiagnoses between similar tumour entities is high, and often leads to inappropriate tumour treatment. We summarize here the main features of fibrosarcoma. When fibrosarcoma is appropriately diagnosed, the patient's overall prognosis is generally quite poor. Fibrosarcoma is characterized by its low sensitivity towards radio-and chemotherapy as well as by its high rate of tumour recurrences. Thus it is important to identify new methods to improve treatment of this tumour entity. We discuss some promising new directions in fibrosarcoma research, specifically focusing on more effective targeting of the tumour microenvironment. Communication between tumour cells and their surrounding stromal tissue play a crucial role in cancer progression, invasion, metastasis and chemosensitivity. The therapeutic potential of targeting the tumour microenvironment is addressed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Augsburger, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, Peter J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalinski, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Udelnow, AndrejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knoesel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofstetter, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qin, Ji WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, YanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sen Gupta, ArvidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonifatius, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, MinglunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, Christiane J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, YueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-210879
DOI: 10.18632/oncotarget.20136
Journal or Publication Title: Oncotarget
Volume: 8
Number: 61
Page Range: S. 104638 - 104654
Date: 2017
Publisher: IMPACT JOURNALS LLC
Place of Publication: ORCHARD PARK
ISSN: 1949-2553
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SOFT-TISSUE SARCOMAS; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; MATRIX METALLOPROTEINASES; DERMATOFIBROSARCOMA PROTUBERANS; TUMOR MICROENVIRONMENT; MULTIDRUG-RESISTANCE; EXTRACELLULAR-MATRIX; SIGNALING PATHWAY; DRUG-RESISTANCEMultiple languages
Oncology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21087

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