Universität zu Köln

Kiechle, Marion, Dukatz, Ricarda, Yahiaoui-Doktor, Maryam ORCID: 0000-0002-3321-1598, Berling, Anika, Basrai, Maryam, Staiger, Vera, Niederberger, Uwe ORCID: 0000-0003-3099-0183, Marter, Nicole, Lammert, Jacqueline ORCID: 0000-0002-0380-574X, Grill, Sabine, Pfeifer, Katharina, Rhiem, Kerstin, Schmutzler, Rita K., Laudes, Matthias, Siniatchkin, Michael, Halle, Martin ORCID: 0000-0003-3065-530X, Bischoff, Stephan C. and Engel, Christoph ORCID: 0000-0002-7247-282X (2017). Feasibility of structured endurance training and Mediterranean diet in BRCA1 and BRCA2 mutation carriers - an interventional randomized controlled multicenter trial (LIBRE-1). BMC Cancer, 17. LONDON: BIOMED CENTRAL LTD. ISSN 1471-2407

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Abstract

Background: Women with pathogenic BRCA germline mutations have an increased risk for breast and ovarian cancer that seems to be modified by life-style factors. Though, randomized trials investigating the impact of lifestyle interventions on cancer prevention and prognosis in BRCA carriers are still missing. Methods: We implemented a multicenter, prospective randomized controlled trial in BRCA1/2 patients, comparing a lifestyle intervention group (IG) with a control group (CG) with the primary aim to prove feasibility. Intervention comprised a structured, individualized endurance training alongside nutrition education based on the Mediterranean diet (MD) for 3 months, plus monthly group training and regular telephone contact during the subsequent 9 months. The CG attended one session on healthy nutrition and the benefits of physical activity. Primary endpoints were feasibility, acceptance and satisfaction over 12 months. Furthermore, effects on physical fitness, diet profile, body mass index (BMI), quality of life and perceived stress were investigated. Results: Sixty-eight participants (mean age 41, mean BMI 23.2 kg/m(2)) were enrolled, of whom 55 (81%, 26 IG, 29 CG) completed 12 months. 73% (n = 26) participated in at least 70% of all intervention sessions. Predictors for drop-outs (19%; n = 13) or non-adherence (27%; n = 7) were not found. 73% rated the program highly and 80% would participate again. Severe adverse events did not occur. Positive effects in the IG compared to the CG were observed for secondary endpoints: BMI, MD eating pattern and stress levels. Conclusions: This lifestyle intervention was feasible, safe and well accepted. Positive results on eating habits, physical fitness and stress levels warrant a larger randomized trial.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kiechle, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Dukatz, Ricarda UNSPECIFIED UNSPECIFIED UNSPECIFIED Yahiaoui-Doktor, Maryam UNSPECIFIED orcid.org/0000-0002-3321-1598 UNSPECIFIED Berling, Anika UNSPECIFIED UNSPECIFIED UNSPECIFIED Basrai, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Staiger, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Niederberger, Uwe UNSPECIFIED orcid.org/0000-0003-3099-0183 UNSPECIFIED Marter, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Lammert, Jacqueline UNSPECIFIED orcid.org/0000-0002-0380-574X UNSPECIFIED Grill, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeifer, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laudes, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Siniatchkin, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Halle, Martin UNSPECIFIED orcid.org/0000-0003-3065-530X UNSPECIFIED Bischoff, Stephan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Christoph UNSPECIFIED orcid.org/0000-0002-7247-282X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211332
DOI:	10.1186/s12885-017-3732-4
Journal or Publication Title:	BMC Cancer
Volume:	17
Date:	2017
Publisher:	BIOMED CENTRAL LTD
Place of Publication:	LONDON
ISSN:	1471-2407
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAGE BREAST-CANCER; LIFE-STYLE INTERVENTION; PHYSICAL-ACTIVITY; ADJUVANT CHEMOTHERAPY; EUROPEAN-ORGANIZATION; POSTMENOPAUSAL WOMEN; RELATIVE VALIDITY; NUTRITION; ADULTS; RISK Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21133