Universität zu Köln

Stoeckigt, Florian, Beiert, Thomas, Knappe, Vincent, Baris, Olivier R., Wiesner, Rudolf J., Clemen, Christoph S., Nickenig, Georg, Andrie, Rene P. and Schrickel, Jan W. (2017). Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction. Biochem. Biophys. Res. Commun., 493 (1). S. 604 - 611. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2104

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Abstract

Background: During aging a mosaic of normal cells and cells with mitochondrial deficiency develops in various tissues including the heart. Whether this contributes to higher susceptibility for arrhythmia following myocardial infarction (MI) is unknown. Methods and Results: Myocardial cryoinfarction was performed in 12-month-old transgenic mice with accelerated accumulation of deletions in mitochondrial DNA. Occurrence and pathogenesis of arrhythmia was investigated after two weeks. Holter-ECG recordings revealed higher rates of premature ventricular complexes (incidence > 10/24 h: 100% vs. 20%; p = 0.048) and more severe spontaneous arrhythmia during stress test in mutant mice with MI as compared to control mice with MI. Mice with mitochondrial dysfunction exhibited longer spontaneous AV-blocks (467 +/- 26 ms vs. 377 +/- 24 ms; p = 0.013), an increased probability for induction of ventricular tachycardia during in vivo electrophysiological investigation (22% vs. 9%; p = 0.044), and a reduced conduction velocity in the infarct borderzone (38.5 +/- 0.5 cm/s vs. 55.3 +/- 0.9 cm/s; p = 0.001). Furthermore, mutant mice exhibited a significant reduction of the phospho-Cx43/Cx43 ratio in right (0.59 +/- 0.04 vs. 0.85 +/- 0.01; p = 0.027) and left ventricular myocardium (0.72 +/- 0.01 vs. 0.86 +/- 0.02; p = 0.023). Conclusions: Aging-related cardiac mosaic respiratory chain dysfunction facilitates the occurrence of spontaneous and inducible cardiac arrhythmia after myocardial infarction and is associated with slowing of electrical impulse propagation in the infarct borderzone. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stoeckigt, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Beiert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Knappe, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Baris, Olivier R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiesner, Rudolf J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clemen, Christoph S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrie, Rene P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schrickel, Jan W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211513
DOI:	10.1016/j.bbrc.2017.08.145
Journal or Publication Title:	Biochem. Biophys. Res. Commun.
Volume:	493
Number:	1
Page Range:	S. 604 - 611
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2104
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONDUCTION DISORDERS; CARDIAC-ARRHYTHMIAS; ATRIAL-FIBRILLATION; HEART; RISK; CARDIOMYOCYTES; ENGRAFTMENT; PREVALENCE; AMERICAN; BEATS Multiple languages Biochemistry & Molecular Biology; Biophysics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21151