Universität zu Köln

Wurzinger, Bernhard ORCID: 0000-0002-9302-2967, Mair, Andrea ORCID: 0000-0002-2492-4318, Fischer-Schrader, Katrin ORCID: 0000-0003-4532-8918, Nukarinen, Ella ORCID: 0000-0002-7092-2305, Roustan, Valentin, Weckwerth, Wolfram ORCID: 0000-0002-9719-6358 and Teige, Markus ORCID: 0000-0001-7204-1379 (2017). Redox state-dependent modulation of plant SnRK1 kinase activity differs from AMPK regulation in animals. FEBS Lett., 591 (21). S. 3625 - 3637. HOBOKEN: WILEY. ISSN 1873-3468

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Abstract

The evolutionarily highly conserved SNF1-related protein kinase (SnRK1) protein kinase is a metabolic master regulator in plants, balancing the critical energy consumption between growth- and stress response-related metabolic pathways. While the regulation of the mammalian [AMP-activated protein kinase (AMPK)] and yeast (SNF1) orthologues of SnRK1 is well-characterised, the regulation of SnRK1 kinase activity in plants is still an open question. Here we report that the activity and T-loop phosphorylation of AKIN10, the kinase subunit of the SnRK1 complex, is regulated by the redox status. Although this regulation is dependent on a conserved cysteine residue, the underlying mechanism is different to the redox regulation of animal AMPK and has functional implications for the regulation of the kinase complex in plants under stress conditions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wurzinger, Bernhard UNSPECIFIED orcid.org/0000-0002-9302-2967 UNSPECIFIED Mair, Andrea UNSPECIFIED orcid.org/0000-0002-2492-4318 UNSPECIFIED Fischer-Schrader, Katrin UNSPECIFIED orcid.org/0000-0003-4532-8918 UNSPECIFIED Nukarinen, Ella UNSPECIFIED orcid.org/0000-0002-7092-2305 UNSPECIFIED Roustan, Valentin UNSPECIFIED UNSPECIFIED UNSPECIFIED Weckwerth, Wolfram UNSPECIFIED orcid.org/0000-0002-9719-6358 UNSPECIFIED Teige, Markus UNSPECIFIED orcid.org/0000-0001-7204-1379 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-212544
DOI:	10.1002/1873-3468.12852
Journal or Publication Title:	FEBS Lett.
Volume:	591
Number:	21
Page Range:	S. 3625 - 3637
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1873-3468
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACTIVATED PROTEIN-KINASE; ARABIDOPSIS-THALIANA; QUANTITATIVE PHOSPHOPROTEOMICS; ENERGY DEPRIVATION; NITRATE REDUCTASE; STRUCTURAL BASIS; MAMMALIAN AMPK; YEAST; PHOSPHORYLATION; INHIBITION Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21254