Scheid, C., de Wreede, L., van Biezen, A., Koenecke, C., Gohring, G., Volin, L., Maertens, J., Finke, J., Passweg, J., Beelen, D., Cornelissen, J. J., Itaelae-Remes, M., Chevallier, P., Russell, N., Petersen, E., Milpied, N., Espiga, C. Richard, Peniket, A., Sierra, J., Mufti, G., Crawley, C., Veelken, J. H., Ljungman, P., Cahn, J. Y., Alessandrino, E. P., de Witte, T., Robin, M. and Kroeger, N. (2017). Validation of the revised IPSS at transplant in patients with myelodysplastic syndrome/transformed acute myelogenous leukemia receiving allogeneic stem cell transplantation: a retrospective analysis of the EBMT chronic malignancies working party. Bone Marrow Transplant., 52 (11). S. 1519 - 1526. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

The International Prognostic Scoring System has been revised (IPSS-R) to predict prognosis of patients with myelodysplastic syndromes at diagnosis. To validate the use of the IPSS-R assessed before transplant rather than at diagnosis we performed a retrospective analysis of the EBMT database. A total of 579 patients had sufficient information available to calculate IPSS-R at transplant. Median overall survival (OS) from transplant was significantly different according to IPSS-R: very low 23.6 months, low 55.0 months, intermediate 19.7 months, high 13.5 months, very high 7.8 months (P < 0.001). In a multivariate Cox model the following parameters were significant risk factors for OS: IPSS-R, graft source, age and prior treatment. Median relapse free survival also showed significant differences according to IPSS-R: very low: 23.6 months, low: 24.8 months, intermediate 10.6 months, high 7.9 months, very high 5.5 months (P < 0.001). Multivariate risk factors for relapse-free survival (RFS) were: IPSS-R, reduced intensity conditioning, graft source and prior treatment. A trend for an increased relapse incidence was noted for very high risk IPSS-R. We conclude that the IPSS-R at transplant is a useful prognostic score for predicting OS and RFS after transplantation, capturing both disease evolution and response to prior treatment before transplant.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Scheid, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Wreede, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Biezen, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenecke, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gohring, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volin, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maertens, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finke, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Passweg, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beelen, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornelissen, J. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Itaelae-Remes, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chevallier, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petersen, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milpied, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espiga, C. RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peniket, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sierra, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mufti, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crawley, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veelken, J. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ljungman, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cahn, J. Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alessandrino, E. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Witte, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robin, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroeger, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-212699
DOI: 10.1038/bmt.2017.171
Journal or Publication Title: Bone Marrow Transplant.
Volume: 52
Number: 11
Page Range: S. 1519 - 1526
Date: 2017
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PROGNOSTIC SCORING SYSTEM; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; MONOSOMAL KARYOTYPE; MDS; CLASSIFICATION; CYTOGENETICS; OUTCOMES; SOCIETYMultiple languages
Biophysics; Oncology; Hematology; Immunology; TransplantationMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21269

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