Universität zu Köln

Drozhzhyna, Galyna I., Gaidamaka, Tetiana B., Cursiefen, Claus, Bachmann, Bjorn O., Ivanovska, Olena V., Ostashevsky, Viktor L., Kogan, BorisM., Usov, Volodymyr J. and Pasyechnikova, Natalija V. (2017). Emergency Keratoplasty with Porcine Xenografts in Necrotizing Keratitis. Klinische Monatsblat. Augenheilkunde, 234 (11). S. 1387 - 1396. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Background The great shortage of donor material in Ukraine makes it necessary to find additional sources of transplant material. A possible suitable material are the porcine corneas, as they are similar in structure and biomechanical parameters to the human cornea. The purpose of our study was to analyze the results of therapeutic keratoplasty (KP) with keratoxenotransplants from cryolyophilized porcine corneas in patients with severe necrotizing keratitis. Methods A retrospective analysis of 32 xenotransplantations patients with severe necrotizing keratitis (17 lamellar, 6 stepped perforating, 4 perforating, 5 biological coverage according to Puchkovskaya) was completed. Results All eyes could be preserved, but the graft was rejected in all eyes. A semitransparent xenograft (XG) was achieved in 9 patients (33.3%). The best results were obtained after lamellar XKP with an XT diameter of 3.5-6.5mm. Lamellar XTs with larger diameters (7.0-10.0mm) were opaque. Postoperatively, the intensity of the inflammatory response after stepped XKP was slightly lower than that of the classical perforating XKP. A new KP with human corneas had to be performed in 5 patients, in one case combined with an antiglaucomatous operation and in another case with cataract extraction. Antiglaucomatous surgery had to be performed in 5 patients (15.6%). Conclusion In the absence of human donor corneas, a porcine keratoxenoimplant can be used as temporary therapeutic keratoplasty in case of emergency stop the inflammation process and to save the eye. In cases of keratoxenoimplant, a poor visual outcome is expected.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Drozhzhyna, Galyna I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaidamaka, Tetiana B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjorn O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ivanovska, Olena V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostashevsky, Viktor L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kogan, BorisM. UNSPECIFIED UNSPECIFIED UNSPECIFIED Usov, Volodymyr J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pasyechnikova, Natalija V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-213562
DOI:	10.1055/s-0043-109694
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	234
Number:	11
Page Range:	S. 1387 - 1396
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSGENIC PIGS; XENOTRANSPLANTATION; GENE Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21356