Universität zu Köln

Vallecillo-Garcia, Pedro, Orgeur, Mickael, vom Hofe-Schneider, Sophie, Stumm, Juergen, Kappert, Verena, Ibrahim, Daniel M., Boerno, Stefan T., Hayashi, Shinichiro ORCID: 0000-0001-5553-7698, Relaix, Frederic ORCID: 0000-0003-1270-1472, Hildebrandt, Katrin, Sengle, Gerhard, Koch, Manuel, Timmermann, Bernd, Marazzi, Giovanna, Sassoon, David A., Duprez, Delphine ORCID: 0000-0003-0248-7417 and Stricker, Sigmar ORCID: 0000-0002-7174-5363 (2017). Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat. Commun., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Fibro-adipogenic progenitors (FAPs) are an interstitial cell population in adult skeletal muscle that support muscle regeneration. During development, interstitial muscle connective tissue (MCT) cells support proper muscle patterning, however the underlying molecular mechanisms are not well understood and it remains unclear whether adult FAPs and embryonic MCT cells share a common lineage. We show here that mouse embryonic limb MCT cells expressing the transcription factor Osr1, differentiate into fibrogenic and adipogenic cells in vivo and in vitro defining an embryonic FAP-like population. Genetic lineage tracing shows that developmental Osr1(+) cells give rise to a subset of adult FAPs. Loss of Osr1 function leads to a reduction of myogenic progenitor proliferation and survival resulting in limb muscle patterning defects. Transcriptome and functional analyses reveal that Osr1(+) cells provide a critical pro-myogenic niche via the production of MCT specific extracellular matrix components and secreted signaling factors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vallecillo-Garcia, Pedro UNSPECIFIED UNSPECIFIED UNSPECIFIED Orgeur, Mickael UNSPECIFIED UNSPECIFIED UNSPECIFIED vom Hofe-Schneider, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Stumm, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kappert, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Ibrahim, Daniel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boerno, Stefan T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hayashi, Shinichiro UNSPECIFIED orcid.org/0000-0001-5553-7698 UNSPECIFIED Relaix, Frederic UNSPECIFIED orcid.org/0000-0003-1270-1472 UNSPECIFIED Hildebrandt, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sengle, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Marazzi, Giovanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Sassoon, David A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Duprez, Delphine UNSPECIFIED orcid.org/0000-0003-0248-7417 UNSPECIFIED Stricker, Sigmar UNSPECIFIED orcid.org/0000-0002-7174-5363 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-213824
DOI:	10.1038/s41467-017-01120-3
Journal or Publication Title:	Nat. Commun.
Volume:	8
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONNECTIVE-TISSUE FIBROBLASTS; CHEMOKINE RECEPTOR CXCR4; EXTRACELLULAR-MATRIX; SATELLITE CELLS; MESENCHYMAL PROGENITORS; MUSCLE SATELLITE; STEM-CELLS; COLLAGEN; EXPRESSION; TENDON Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21382