Universität zu Köln

Zimmer, Philipp, Bloch, Wilhelm, Kieven, Markus, Loevenich, Lukas, Lehmann, Jonas, Holthaus, Michelle, Theurich, Sebastian ORCID: 0000-0001-5706-8258 and Schenk, Alexander (2017). Serotonin Shapes the Migratory Potential of NK Cells - An in vitro Approach. Int. J. Sports Med., 38 (11). S. 857 - 864. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3964

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Abstract

Increased serotonin (5-HT) levels have been shown to influence natural killer cell (NK cell) function. Acute exercise mobilizes and activates NK cells and further increases serum 5-HT concentrations in a dose-dependent manner. The aim of this study was to investigate the impact of different serum 5-HT concentrations on NK cell migratory potential and cytotoxicity. The human NK cell line KHYG-1 was assigned to 4 conditions, including 3 physiological concentrations of 5-HT (100, 130 or 170 mu g/l 5-HT) and one control condition. NK cells were analyzed regarding cytotoxicity, migratory potential and expression of adhesion molecules. No treatment effect on NK cell cytotoxicity and expression of integrin subunits was detected. Migratory potential was increased in a dose dependent manner, indicating the highest protease activity in cells that were incubated with 170 mu g/l 5-HT (170 mu g/l vs. control, p < 0.001, 170 mu g/l vs. 100 mu g/l, p < 0.001; 170 mu g/l vs. 130 mu g/l, p = 0.003; 130 mu g/l vs. control, p < 0.001, 130 mu g/l vs. 100 mu g/l, p < 0.001). These results suggest that elevated 5-HT serum levels play a mediating role in NK cell function. As exercise has been shown to be involved in NK cell mobilization and redistribution, the influence of 5-HT should be investigated in ex vivo and in vivo experiments.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Kieven, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Loevenich, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Holthaus, Michelle UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215546
DOI:	10.1055/s-0043-113042
Journal or Publication Title:	Int. J. Sports Med.
Volume:	38
Number:	11
Page Range:	S. 857 - 864
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3964
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NATURAL-KILLER-CELLS; RESISTANCE EXERCISE; ADHESION MOLECULES; AEROBIC EXERCISE; CYTOTOXICITY; EXPRESSION; RESPONSES; MOBILIZATION; ENHANCEMENT; RECEPTORS Multiple languages Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21554