Universität zu Köln

Persigehl, T., Poeppel, T. D. and Sedlaczek, O. (2017). Radiological response assessment of modern immunotherapy using iRECIST. Radiologe, 57 (10). S. 826 - 834. NEW YORK: SPRINGER. ISSN 1432-2102

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Abstract

Clinical/methodical issue. Modern immunotherapies in oncology show tumor response patterns differing from conventional chemotherapies including initial pseudo-progression. Standard radiological methods. Response evaluation criteria in solid tumors (RECIST 1.1) represent the currently most used response criteria for conventional chemotherapy of solid tumors. However, atypical response patterns of immunotherapies are not correctly classified using RECIST 1.1 so that the effectiveness is also incorrectly interpreted. Methodical innovations. In order to correctly interpret these atypical response patterns, special immune-related response criteria in solid tumors (iRECIST) have been published. In contrast to RECIST 1.1 according to iRECIST an initially unconfirmed progressive disease (iUPD) requires confirmation (iCPD) in clinically stable patients by subsequent control imaging after 4-8 weeks. New lesions are separately assessed within iRECIST. Performance. The iRECIST procedure allows a standardized objective assessment of a possible pseudo-progression which can occur in up to 10% of cases depending on the immunomodulating drug and tumor entity. Achievements. In principle, iRECIST was developed only for usage in trials testing modern immunotherapeutics. Practical recommendations. The iRECIST procedure might also be helpful as an additional objective response criterium for clinical treatment decisions, taking the limitations into account.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Persigehl, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Poeppel, T. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sedlaczek, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215959
DOI:	10.1007/s00117-017-0289-9
Journal or Publication Title:	Radiologe
Volume:	57
Number:	10
Page Range:	S. 826 - 834
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-2102
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOLID TUMORS; CANCER; CRITERIA; RECIST; GUIDELINES; THERAPY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21595