Waniek, Sabina ORCID: 0000-0003-4381-9676, di Giuseppe, Romina, Plachta-Danielzik, Sandra, Ratjen, Ilka, Jacobs, Gunnar, Koch, Manja ORCID: 0000-0002-4794-4821, Borggrefe, Jan ORCID: 0000-0003-2908-7560, Both, Marcus, Mueller, Hans-Peter, Kassubek, Jan ORCID: 0000-0002-7106-9270, Noethlings, Ute, Esatbeyoglu, Tuba ORCID: 0000-0003-2413-6925, Schlesinger, Sabrina ORCID: 0000-0003-4244-0832, Rimbach, Gerald ORCID: 0000-0001-7888-4684 and Lieb, Wolfgang (2017). Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived Body Fat Volumes and Liver Fat Content. Nutrients, 9 (10). BASEL: MDPI. ISSN 2072-6643

Full text not available from this repository.

Abstract

We aimed to relate circulating alpha- and gamma-tocopherol levels to a broad spectrum of adiposity-related traits in a cross-sectional Northern German study. Anthropometric measures were obtained, and adipose tissue volumes and liver fat were quantified by magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women). Concentrations of alpha- and gamma-tocopherol were measured using high performance liquid chromatography. Multivariable-adjusted linear and logistic regression were used to assess associations of circulating alpha- and gamma-tocopherol/cholesterol ratio levels with visceral (VAT) and subcutaneous adipose tissue (SAT), liver signal intensity (LSI), fatty liver disease (FLD), metabolic syndrome (MetS), and its individual components. The gamma-tocopherol/cholesterol ratio was positively associated with VAT (scaled by interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR): 1.83; 95% CI: 1.21-2.76 for 3rd vs. 1st tertile), and the gamma-tocopherol/cholesterol ratio was positively associated with VAT ( scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT ( scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile). alpha- and gamma-tocopherol levels were positively associated with high triglycerides and low high density lipoprotein cholesterol levels (all P-trend < 0.05). No association of alpha- and gamma-tocopherol/cholesterol ratio with LSI/FLD was observed. Circulating vitamin E levels displayed strong associations with VAT and MetS. These observations lay the ground for further investigation in longitudinal studies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Waniek, SabinaUNSPECIFIEDorcid.org/0000-0003-4381-9676UNSPECIFIED
di Giuseppe, RominaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plachta-Danielzik, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ratjen, IlkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobs, GunnarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koch, ManjaUNSPECIFIEDorcid.org/0000-0002-4794-4821UNSPECIFIED
Borggrefe, JanUNSPECIFIEDorcid.org/0000-0003-2908-7560UNSPECIFIED
Both, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kassubek, JanUNSPECIFIEDorcid.org/0000-0002-7106-9270UNSPECIFIED
Noethlings, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esatbeyoglu, TubaUNSPECIFIEDorcid.org/0000-0003-2413-6925UNSPECIFIED
Schlesinger, SabrinaUNSPECIFIEDorcid.org/0000-0003-4244-0832UNSPECIFIED
Rimbach, GeraldUNSPECIFIEDorcid.org/0000-0001-7888-4684UNSPECIFIED
Lieb, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-216939
DOI: 10.3390/nu9101143
Journal or Publication Title: Nutrients
Volume: 9
Number: 10
Date: 2017
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6643
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TOCOPHEROL TRANSFER PROTEIN; ALPHA-TOCOPHEROL; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS; ANTIOXIDANT CONCENTRATIONS; SERUM CONCENTRATIONS; ADIPOSE-TISSUE; BETA-CAROTENE; PLASMA-LEVELS; DOUBLE-BLINDMultiple languages
Nutrition & DieteticsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21693

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item