Universität zu Köln

Hoepken, Merle, Reitmajer, Markus, Silling, Steffi, Maune, Steffen, Brockmann, Michael and Schildgen, Oliver ORCID: 0000-0003-4297-9627 (2017). Novel DNA CHIP detects human papillomaviruses in tonsillar tumors. Future Virol., 12 (9). S. 513 - 519. LONDON: FUTURE MEDICINE LTD. ISSN 1746-0808

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Abstract

Aim: In this study, the novel VisionArray HPV assay was compared with the LCD CHIP array for the detection of HPVs in tonsillar carcinoma. Materials & methods: A Panel of tonsillar tumors and control samples containing know HPV isolates were tested with the VisonArry HPV Assay (Zytovision, Bremerhaven, Germany) and the Chipron MycoDirect LCD Assay (Chipron, Berlin, Germany). Results: While both assays enabled the discrimination between low-risk, intermediate and high-risk types, the LCD CHIP assay had a better laboratory performance and was more comfortable in its usage. However, both arrays delivered comparable results. Conclusion: Both assays are appropriate tools for the detection of clinically relevant HPV strains in tonsillar tumors. However, if the LCD CHIP array is established, the more complex workflow required for the VisionArray HPV assay could restrain diagnostic labs from a change to this novel assay despite its good quality.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoepken, Merle UNSPECIFIED UNSPECIFIED UNSPECIFIED Reitmajer, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Silling, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Maune, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-218440
DOI:	10.2217/fvl-2017-0053
Journal or Publication Title:	Future Virol.
Volume:	12
Number:	9
Page Range:	S. 513 - 519
Date:	2017
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1746-0808
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; NECK-CANCER; HEAD; TISSUE; VIRUS; P16 Multiple languages Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21844