Universität zu Köln

Kirchhof, Bernd (2017). Cell Transplantation in Age-related Macular Degeneration. Klinische Monatsblat. Augenheilkunde, 234 (9). S. 1082 - 1088. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Robert Machemer offers a surgical approach to age-related macular degeneration with his retinal rotation. There is already considerable experimental and clinical knowledge available in Europe and the US on transplantation techniques for age-related macular degeneration. On average, initial visual acuity can be preserved. When photodynamic therapy was standard for exudative AMD, transplantation was superior. Photodynamic therapy could not stop, but was instead able to slow down visual loss. Currently, VEGF-blocker therapy has priority, because the visual acuity can be improved. However, this advantage does not last much longer than two years. Therefore, in the future, transplantation with new cells and less surgical risk may be reconsidered. At present, homologous RPE stem cells show promising results. They may be delivered as sheets or as single cells. For dry AMD only, a prophylactic approach seems reasonable, because, thus far, we are unable to reverse the atrophy on the retinal side.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-219782
DOI:	10.1055/s-0043-111802
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	234
Number:	9
Page Range:	S. 1082 - 1088
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETINAL-PIGMENT EPITHELIUM; AUTOLOGOUS TRANSLOCATION; STEM-CELLS; RPE; SECONDARY; ATROPHY; MATRIX Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21978